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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Induction of Apoptosis by [8]-Shogaol via Reactive Oxygen Species Generation, Glutathione Depletion, and Caspase Activation in Human Leukemia Cells
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Induction of Apoptosis by [8]-Shogaol via Reactive Oxygen Species Generation, Glutathione Depletion, and Caspase Activation in Human Leukemia Cells

机译：在人类白血病细胞中通过[8] -Shogaol通过活性氧的产生，谷胱甘肽耗竭和胱天蛋白酶激活来诱导细胞凋亡。

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摘要

Ginger, the rhizome of Zingiber officinale, is a traditional medicine with a carminative effect and antinausea, anti-inflammatory, and anticaroinogenic properties. This study examined the growth inhibitory effects of [8]-shogaol, one of the pungent phenolic compounds in ginger, on human leukemia HL-60 cells. It demonstrated that [8]-shogaol was able to induce apoptosis in a time- and concentration-dependent manner. Treatment with [8]-shogaol caused a rapid loss of mitochondrial transmembrane potential, stimulation of reactive oxygen species (ROS) production, release of mitochondrial cytochrome c into cytosol, and subsequent induction of procaspase-9 and procaspase-3 processing. Taken together, these results suggest for the first time that ROS production and depletion of glutathione that contributed to [8]-shogaol-induced apoptosis in HL-60 cells.
机译：生姜，姜的根茎，是一种传统的药物，具有致癌作用和抗恶心，消炎和抗龋齿作用。这项研究检查了生姜中刺激性酚类化合物之一[8] -shogaol对人白血病HL-60细胞的生长抑制作用。证明[8]-松果酚能够以时间和浓度依赖性方式诱导细胞凋亡。 [8] -shogaol处理导致线粒体跨膜电位快速丧失，刺激了活性氧（ROS）的产生，线粒体细胞色素c释放到胞质溶胶中，随后诱导了procaspase-9和procaspase-3加工。综上所述，这些结果首次表明ROS的产生和谷胱甘肽的消耗促成[8] -shogaol诱导的HL-60细胞凋亡。

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