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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Monascin and Ankaflavin Act as Novel Hypolipidemic and High-Density Lipoprotein Cholesterol-Raising Agents in Red Mold Dioscorea
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Monascin and Ankaflavin Act as Novel Hypolipidemic and High-Density Lipoprotein Cholesterol-Raising Agents in Red Mold Dioscorea

机译：莫纳辛和Ankaflavin在红薯薯os中作为新型降血脂和高密度脂蛋白胆固醇升高剂

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摘要

Monascus-femnented red mold dioscorea (RMD) has been proven to possess greater hypolipidemic effect than red mold rice (RMR) even though they include equal levels of cholesterol-lowering agent monacolin K. However, higher concentrations of yellow pigments (monascin and ankaflavin) were found in RMD than in RMR. In this study, purified monascin and ankaflavin were administered to hyperlipidemic hamsters for 8 weeks, respectively, to test whether these two compounds were novel hypolipidemic ingredients. In the statistical results, monascin and ankaflavin showed significant effect on lowering cholesterol, triglyceride, and low-density lipoprotein cholesterol levels in serum, as well as aorta lipid plaque (p < 0.05). Importantly, monascin and ankaflavin, unlike monacolin K, were able to perform up-regulation rather than down-regulation oh high-density lipoprotein cholesterol (HDL-C) levels in serum. This finding not only explained why RMD showed greater hypolipidemic and HDL-C-raising effect than RMR but also proved that monascin and ankaflavin would act as novel and potent hypolipidemic ingredients.
机译：已证明红曲霉红霉薯di（RMD）的降血脂作用比红霉米（RMR）更高，即使它们包含相同水平的降胆固醇剂莫纳可琳K。但是，较高浓度的黄色颜料（莫纳辛和ankaflavin）在RMD中比在RMR中发现。在这项研究中，分别对高脂血症仓鼠施用纯化的莫纳霉素和ankaflavin 8周，以测试这两种化合物是否为新型降血脂成分。在统计结果中，莫纳辛和ankaflavin对降低血清以及主动脉脂质斑块中的胆固醇，甘油三酸酯和低密度脂蛋白胆固醇水平具有显著作用（p <0.05）。重要的是，与莫纳可林K不同，莫纳辛和ankaflavin能够在血清中高密度脂蛋白胆固醇（HDL-C）水平上调而不是下调。这一发现不仅解释了为什么RMD表现出比RMR更高的降血脂和HDL-C升高作用，而且还证明了莫纳辛和Ankaflavin将作为新型有效的降血脂成分。

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