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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Chemical Characterization of the Avenanthramide-Rich Extract from Oat and Its Effect on D-Galactose-lnduced Oxidative Stress in Mice
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Chemical Characterization of the Avenanthramide-Rich Extract from Oat and Its Effect on D-Galactose-lnduced Oxidative Stress in Mice

机译：燕麦中富含Avannanthramide的提取物的化学表征及其对D-半乳糖诱导的小鼠氧化应激的影响

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摘要

The present study was to characterize the avenanthramide-rich extract (ARE) from oat bran and assess its effect on activity and gene expression of antioxidant enzymes in D-galactose-induced oxidatlve-stressed mice. High-performance liquid chromatography (HPLC) analysis found that ARE had 6.07% N-(3',4'-dihydroxycinnamoyl)-5-hydroxyanthranilic acid (Bc), 4.37% N-(4'-hydroxycinnamoyl)-5-hydro-xyanthranilic acid (Bp), and 5.36% N-(4'-hydroxy-3'-methoxycinnamoyl)-5-hydroxyanthranilic acid (Bf). In addition, ARE was also rich in vanillic acid (0.60%), caffeic acid (0.50%), syrlngic acid (0.54%), p-coumaric acid (0.16%), ferulic acid (0.08%), and sinapic acid (0.03%). Administration of D-galactose markedly lowered not only the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) but also the gene expression of manganese superoxide dismutase (SOD), copper-zinc SOD, glutathione peroxidase (GPx), and lipoprotein lipase (LPL) mRNA in mice. Administration of ARE significantly reversed the D-galactose-induced oxidative stress by increasing the activity of the antioxidant enzymes and upregulating their gene expression. This was accompanied by a significant decrease in the malondialdehyde (MDA) level in mice given ARE compared to the control. The results demonstrated that ARE possessed the antioxidant activity and was effective against D-galactose-induced oxidative stress.
机译：本研究旨在表征燕麦麸中富含金刚烷酰胺的提取物（ARE），并评估其对D-半乳糖诱导的氧化应激小鼠体内抗氧化酶活性和基因表达的影响。高效液相色谱（HPLC）分析发现，ARE具有6.07％的N-（3'，4'-二羟基肉桂酰基）-5-羟基邻氨基苯甲酸（Bc），4.37％的N-（4'-羟基肉桂酰基）-5-氢-邻氨基苯甲酸（Bp）和5.36％的N-（4'-羟基-3'-甲氧基肉桂酰基）-5-羟基邻氨基苯甲酸（Bf）。此外，ARE还含有丰富的香草酸（0.60％），咖啡酸（0.50％），山梨酸（0.54％），对香豆酸（0.16％），阿魏酸（0.08％）和芥子酸（0.03） ％）。 D-半乳糖的施用不仅显着降低了超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GPx）的活性，而且显着降低了锰超氧化物歧化酶（SOD），铜锌SOD，谷胱甘肽过氧化物酶（GPx）和脂蛋白脂肪酶的基因表达（LPL）mRNA在小鼠中。通过增加抗氧化酶的活性并上调其基因表达，ARE的施用显着逆转了D-半乳糖诱导的氧化应激。与对照组相比，伴有ARE的小鼠丙二醛（MDA）水平显着下降。结果表明，ARE具有抗氧化活性，对D-半乳糖诱导的氧化应激有效。

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