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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Determination of Furaltadone and Nifursol Residues in Poultry Eggs by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry
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Determination of Furaltadone and Nifursol Residues in Poultry Eggs by Liquid Chromatography-Electrospray Ionization Tandem Mass Spectrometry

机译：液相色谱-电喷雾串联质谱法测定禽蛋中的呋喃他酮和呋喃丹残留

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摘要

The use of nitrofurans as veterinary drugs has been banned from intensive animal production in the European Union (EU) since 1993. The objective of the present study was to evaluate the accumulation and depletion of furaltadone and nifursol and their side-chain metabolites 5-methylmorpholino-3-amino-2-oxazoIidinone (AMOZ) and 3,5-dinitrosalicylic acid hydrazide (DNSAH) in eggs after administration of therapeutic and subtherapeutic doses of the drugs to laying hens during three consecutive weeks. LC-MS/MS, with positive and negative electrospray ionization methods, was used for the determination of parent compounds and metabolites in yolk and egg white and was validated according to criteria established by Commission Decision 2002/657/EC. The decision limit (CCα) and the detection capability (CCβ) of the analytical methodology for metabolites were 0.1 and 0.5 μg/kg for AMOZ and 0.3 and 0.9 μg/kg for DNSAH, respectively. For the parent compounds, CCa and CCβ were 0.9 and 2.0 μg/kg for furaltadone and 1.3 and 3.1 μg/kg for nifursol, respectively. The data obtained show that the parent compounds are much less persistent than their side-chain metabolites in either yolk or egg white. Between the studied metabolites, AMOZ is the most persistent and could be detected in either yolk or egg white three weeks following withdrawal from treatment.
机译：自1993年以来，欧盟已禁止在动物密集生产中使用硝基呋喃作为兽药。本研究的目的是评估呋喃他酮和尼糠醇及其侧链代谢产物5-methylmorpholino的积累和消耗。在连续三周内对蛋鸡进行治疗和亚治疗剂量的药物后，鸡蛋中的-3-氨基-2-恶唑烷酮（AMOZ）和3,5-二硝基水杨酸酰肼（DNSAH）。使用正电和负电喷雾电离方法的LC-MS / MS用于测定蛋黄和蛋清中的母体化合物和代谢物，并已根据Commission Decision 2002/657 / EC建立的标准进行了验证。代谢物分析方法的判定极限（CCα）和检测能力（CCβ）对于AMOZ分别为0.1和0.5μg/ kg，对于DNSAH为0.3和0.9μg/ kg。对于母体化合物，呋喃他酮的CCa和CCβ分别为0.9和2.0μg/ kg，尼古丁的CCa和CCβ分别为1.3和3.1μg/ kg。获得的数据表明，无论是蛋黄还是蛋清，母体化合物的持久性都比其侧链代谢物持久性低。在研究的代谢物之间，AMOZ是最持久的，退出治疗三周后可在蛋黄或蛋清中检测到。

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