...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Biology: CB >The CMK-1 CaMKI and the TAX-4 cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C-elegans
【24h】

The CMK-1 CaMKI and the TAX-4 cyclic nucleotide-gated channel regulate thermosensory neuron gene expression and function in C-elegans

机译：CMK-1 CaMKI和TAX-4环状核苷酸门控通道调节C-线虫中的热感神经元基因表达和功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The cultivation temperature (T-c) modulates the thermosensory responses exhibited by C. elegans on thermal gradients [1-5]. The AFD sensory neurons are essential for thermosensory behaviors [2], but the molecular mechanisms by which temperature is sensed and the memory of the T-c is encoded are unknown. Here, we show that the CMK-1 Ca2+/calmodulin-dependent protein kinase I (CaMKI) and the TAX-4 cyclic nucleotide-gated channel regulate gene expression, morphology, and functions of the AFD thermosensory neurons. Mutations in cmk-1 and tax-4 result in temperature-dependent defects in AFD-specific gene expression, and TAX-4 functions are required during larval stages to maintain gene expression in the adult. CMK-1 and TAX-4 act cell autonomously to regulate AFD-mediated thermosensory behaviors. The molecular requirements for CMK-1 activity in the AFD neurons appear to be distinct from those previously described [6, 7]. We propose that the activation of distinct programs of AFD-specific gene expression at different temperatures by CMK-1 and TAX-4 enables C. elegans to sense and/or encode a memory for the T-c.
机译：培养温度（T-c）调节秀丽隐杆线虫在热梯度上表现出的热感响应[1-5]。 AFD感觉神经元是热感觉行为必不可少的[2]，但是尚不清楚通过分子机制来感测温度和编码T-c的记忆。在这里，我们显示，CMK-1 Ca2 + /钙调蛋白依赖性蛋白激酶I（CaMKI）和TAX-4环状核苷酸门控通道调节AFD热感觉神经元的基因表达，形态和功能。 cmk-1和tax-4中的突变会导致AFD特异性基因表达中的温度依赖性缺陷，在幼体阶段需要TAX-4功能来维持成人中的基因表达。 CMK-1和TAX-4自主作用于细胞，以调节AFD介导的热感行为。 AFD神经元中CMK-1活性的分子需求似乎与先前所述的需求不同[6，7]。我们建议通过CMK-1和TAX-4在不同温度下激活AFD特异性基因表达的不同程序，可使秀丽隐杆线虫感测和/或编码T-c的记忆。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号