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首页> 外文期刊>Journal of Agricultural and Food Chemistry >6-Hydroxydaidzein Enhances Adipocyte Differentiation and Glucose Uptake in 3T3-L1 Cells
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6-Hydroxydaidzein Enhances Adipocyte Differentiation and Glucose Uptake in 3T3-L1 Cells

机译：6-羟基黄豆苷元增强3T3-L1细胞的脂肪细胞分化和葡萄糖摄取

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摘要

Fermented soybean foods have been shown to reduce incidence of diabetes and improve insulin sensitivity. 6-Hydroxydaidzein (6-HD) is a bioactive ingredient isolated from fermented soybean. In this study, we examined the effects of 6-HD on adipocyte differentiation and insulin-stimulated glucose uptake, as well as the mechanisms involved. In our experiments, 6-HD enhanced 3T3-L1 adipocyte differentiation and insulin-stimulated glucose uptake in a dosage-dependent manner. In addition, 6-HD increased peroxisome proliferator-activated receptor gamma (PPARγ) gene expression and PPARγ transcriptional activity. 6-HD increased CCAAT/enhanced binding protein alpha (C/EBPα) expression as well. Although having no effects on glucose transporter type 4 (GLUT4) gene expression, 6-HD facilitated GLUT4 protein translocation to the cell membranes. Our results indicate that 6-HD exhibited the actions of promoting adipocyte differentiation and improving insulin sensitivity by increasing the expression of C/EBPα and facilitating the translocation of GLUT4 via the activation of PPARγ, suggesting that 6-HD can be promising in diabetes management.
机译：发酵大豆食品已显示可减少糖尿病的发生并改善胰岛素敏感性。 6-羟基黄豆苷元（6-HD）是一种从发酵大豆中分离出来的生物活性成分。在这项研究中，我们检查了6-HD对脂肪细胞分化和胰岛素刺激的葡萄糖摄取的影响，以及所涉及的机制。在我们的实验中，6-HD以剂量依赖性方式增强3T3-L1脂肪细胞分化和胰岛素刺激的葡萄糖摄取。此外，6-HD增加了过氧化物酶体增殖物激活受体γ（PPARγ）基因表达和PPARγ转录活性。 6-HD也增加了CCAAT /增强的结合蛋白α（C /EBPα）的表达。尽管对4型葡萄糖转运蛋白（GLUT4）基因表达没有影响，但是6-HD促进了GLUT4蛋白向细胞膜的转运。我们的结果表明6-HD通过增加C /EBPα的表达和通过激活PPARγ促进GLUT4的易位而具有促进脂肪细胞分化和改善胰岛素敏感性的作用，这表明6-HD在糖尿病治疗中可能是有希望的。

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