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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087
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Isolation and Characterization of New p-Terphenyls with Antifungal, Antibacterial, and Antioxidant Activities from Halophilic Actinomycete Nocardiopsis gilva YIM 90087

机译：嗜盐放线菌Nocardiopsis gilva YIM 90087的具有抗真菌，抗菌和抗氧化活性的新对-三联苯的分离和表征

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摘要

A new p-terphenyl 1 and a novel p-terphenyl derivative 3 bearing a benzothiazole moiety were isolated from halophilic actinomycete Nocardiopsis gilva YIM 90087, along with known p-terphenyl 2, antibiotic novobiocin 4, cyclodipeptides 5—13, and aromatic acids 14 and 15. Their structures were elucidated on the basis of the interpretation of spectral data and by comparison of the corresponding data with those reported previously. The p-terphenyl 1 showed antifungal activity against the three pathogenic fungi, including Fusarium avenaceum, Fusarium graminearum, and Fusarium culmorum, that caused Fusarium head blight with minimal inhibitory concentrations (MICs) of 8, 16, and 128 μg/mL, respectively. Compound 1 showed antifungal activity against Candida albicans with a MIC of 32 μg/mL and antibacterial activity against Bacillus subtilis with a MIC of. 64 μg/mL. Novobiocin 4 showed antifungal activity against Pyricularia oryzae with a MIC of 16 μg/mL and antibacterial activity against B. subtilis with a MIC of l6 μg/mL and Staphylococcus aureus with a MIC of 64 μg/mL. The 1,1-diphenyl-2-picryl-hydrazyl assay suggested that 1, 3, and 4 exhibited 54.9% (2 mg/mL), 14.3% (4 mg/mL), and 47.7% (2 mg/mL) free radical scavenging activity, respectively. The positively charged 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid radical (ABTS~(+·)) scavenging assay indicated that 1, 3,4, and 8 exhibited 68.6% (1 mg/mL), 28.4% (2 mg/mL), 78.2% (0.5 mg/mL), and 54.6% (2 mg/mL) ABTS~(+·) scavenging capacity, respectively. The superoxide anion radical scavenging assay suggested that 4 exhibited 77.9% superoxide anion radical scavenging capacity at 2 rng/mL. N. gilva YIM 90087 is a new resource for novobiocin 4.
机译：从嗜盐放线菌Nocardiopsis gilva YIM 90087，连同已知的对叔苯基2，抗生素新霉素4，环二肽5-13，和芳香酸14和13，分离了带有苯并噻唑部分的新对叔苯基1和带有苯并噻唑部分的新对叔苯基衍生物3。 15.在解释光谱数据的基础上，并通过将相应数据与先前报告的数据进行比较，阐明了它们的结构。对三联苯1对三种病原真菌（包括镰刀镰刀菌，禾谷镰刀菌和小镰刀菌）表现出抗真菌活性，它们分别以8、16和128μg/ mL的最低抑菌浓度（MIC）引起镰刀菌病。化合物1显示出对白色念珠菌的抗真菌活性，MIC为32μg/ mL，而对枯草芽孢杆菌的抗菌活性为MIC。 64μg/ mL。 Novobiocin 4的米曲霉抗真菌活性为MIC为16μg/ mL，对枯草芽孢杆菌的抑菌活性为MIC为16μg/ mL，金黄色葡萄球菌的抗菌活性为MIC为64μg/ mL。 1,1-二苯基-2-吡啶基-肼基测定表明1,3和4不含54.9％（2 mg / mL），14.3％（4 mg / mL）和47.7％（2 mg / mL）自由基清除活性。带正电的2,2'-叠氮基-双-3-乙基苯并噻唑啉-6-磺酸基（ABTS〜（+·））清除试验表明1、3,4和8表现出68.6％（1 mg / mL）分别具有28.4％（2 mg / mL），78.2％（0.5 mg / mL）和54.6％（2 mg / mL）的ABTS〜（+·）清除能力。超氧阴离子自由基清除实验表明，4个化合物在2 rng / mL时具有77.9％的超氧阴离子自由基清除能力。 N. gilva YIM 90087是新霉素4的新资源。

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