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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Chemical Composition, Antioxidative and Anti-Inflammatory Activity of Extracts Prepared from Aerial Parts of Oenothera biennis L and Oenothera paradoxa Hudziok Obtained after Seeds Cultivation
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Chemical Composition, Antioxidative and Anti-Inflammatory Activity of Extracts Prepared from Aerial Parts of Oenothera biennis L and Oenothera paradoxa Hudziok Obtained after Seeds Cultivation

机译：种子培养后获得的月见草和月见草的气生部分提取物的化学组成，抗氧化和抗炎活性

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摘要

In the present study we investigated the chemical composition of extracts prepared from aerial parts of Oenothera paradoxa Hudziok and Oenothera biennis L. and their antioxidative and anti-inflammatory activities. Ultra high pressure liquid chromatography (UHPLC)-DAD-MS/MS studies showed that both extracts contain a wide variety of polyphenols (39 identified constituents) among which macrocyclic ellagitannin turned out to be the main constituent. During the in vitro studies, using noncellular models, both extracts scavenged reactive oxygen spedes (ROS) in a concentration-dependent manner, and the lowest SC_(50) values were obtained for O2~- and H2O2. Both extracts inhibited ROS production by stimulated human neutrophils. The stronger activity in the case of formyl-met-leu-phenylalanine stimulation suggests that both extracts may act through the receptor-dependent pathway. O. paradoxa extract and 0. biennis extract exhibited anti-inflammatory activity by the inhibition of hyaluronidase and lipoxygenase in a concentration-dependent manner. The stronger activity of O.biennis extract toward lipoxygenase may be explained by its higher oenothein B content.
机译：在本研究中，我们调查了从月见草和月见草的地上部分制备的提取物的化学成分及其抗氧化和抗炎活性。超高压液相色谱（UHPLC）-DAD-MS / MS研究表明，两种提取物均含有多种多酚（已确定39种成分），其中大环鞣花单宁是主要成分。在体外研究过程中，使用非细胞模型，两种提取物均以浓度依赖的方式清除了活性氧（ROS），并获得了最低的O2〜-和H2O2的SC_（50）值。两种提取物均能通过刺激人类嗜中性粒细胞抑制ROS的产生。在甲酰-间-亮-亮-苯丙氨酸刺激的情况下，较强的活性表明这两种提取物都可能通过受体依赖性途径起作用。矛盾的O. paradoxa提取物和0. biennis提取物通过以浓度依赖的方式抑制透明质酸酶和脂氧合酶表现出抗炎活性。牛油菌提取物对脂氧合酶的较强活性可以用其较高的卵泡蛋白B含量来解释。

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