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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome
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Black Currant Anthocyanins Attenuate Weight Gain and Improve Glucose Metabolism in Diet-Induced Obese Mice with Intact, but Not Disrupted, Gut Microbiome

机译：黑醋栗花色苷可减轻饮食诱导的肥胖小鼠的完整体重，但不会破坏肠道微生物组，从而减轻体重，改善其葡萄糖代谢。

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Black currant (Ribes nigrum L.) is a rich source of anthocyanins; however, the relationship between their apparently limited bioavailability and significant protection against metabolic pathologies is poorly understood. This study examined the gastrointestinal distribution, of black currant anthocyanins and their phenolic acid metabolites in lean and diet-induced obese mice with healthy and antibiotic disrupted microbiomes. Daily consumption of low or high fat diet supplemented with 1% black currant powdered,extract (32% anthocyanins) for 8 weeks reduced body weight gain and improved glucose metabolism only in Mice with the intact gut microbiome. Administration of antibiotic cocktail resulted in a 16-25-fold increase P < 0.001) in anthocyanin content of feces, and "cyanidin-based anthocyanins showed the largest increase in fecal content upon disruption of gut microbiome (92.3 +/- 16.3 vs 4719 +/- 158 mu g/g feces), indicating their high susceptibility to microbial degradation in the gut A. 3-fold enrichment (P < 0.05) in gallic over protocatechuic acid was observed in the jejunum of both intact and antibiotic treated animals, suggesting that this effect was likely independent of their gut microbiome status. Taken together, the data clearly demonstrate that gut microbiome and the type of the anthocyanin aglycone moiety can alter the protective effect of anthocyanins against obesity and associated insulin resistance.
机译：黑加仑（Ribes nigrum L.）是花青素的丰富来源。然而，人们对它们表面上有限的生物利用度与针对代谢性疾病的有效保护之间的关系知之甚少。这项研究检查了黑醋栗花色苷及其酚酸代谢产物在健康和抗生素破坏的微生物群和健康饮食的肥胖小鼠中的胃肠道分布。每天摄入低脂或高脂饮食，辅以1％的黑加仑粉，提取物（32％的花青素）提取8周，仅在具有完整肠道微生物组的小鼠中，体重增加减少且葡萄糖代谢改善。抗生素鸡尾酒的使用导致粪便中花色苷含量增加16-25倍，P <0.001），“基于花青素的花色苷在肠道微生物组破坏后显示最大的粪便含量增加（92.3 +/- 16.3 vs 4719 + /-158μg / g的粪便），表明它们对肠道A中的微生物降解高度敏感。在完整和经抗生素处理的动物的空肠中，没食子酸比原儿茶酸高3倍富集（P <0.05）。总之，这些数据清楚地表明，肠道微生物组和花青素糖苷配基部分的类型可以改变花青素对肥胖症和相关胰岛素抵抗的保护作用。

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