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Novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of poly(ethylene glycol)

机译:通过在聚乙二醇存在下丙烯酸模板聚合制备的新型粘膜粘附聚合物

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A new mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of poly(ethylene glycol) (PEG). FTIR results indicated that a polymer complex was formed between poly(acrylic acid) (PAA) and PEG through hydrogen bonding. The hydrogen bonding in the PAA/PEG polymer complex was stronger than that in the PAA/PEG blend, and became stronger as the molecular weight of PEG increased. Glass transition temperatures (Tg) of PAA in the PAA/PEG polymer complexes was shifted to a lower temperature than that of PAA in the PAA/PEG blend. However, they tended to become higher as the molecular weight of PEG increased. The dissolution rate of the PAA/PEG polymer complex was much slower than the PAA/PEG blend, and was dependent on pH and molecular weight of the PEG. The mucoadhesive force of the PAA/PEG polymer complexes was stronger than for the PAA/PEG blend or a commercial product, Carbopol 971P NF.
机译:在聚乙二醇(PEG)存在下,通过丙烯酸的模板聚合反应制备了一种新的粘膜粘附性聚合物。 FTIR结果表明,聚(丙烯酸)(PAA)与PEG之间通过氢键形成了聚合物配合物。 PAA / PEG聚合物络合物中的氢键比PAA / PEG共混物中的氢键强,并且随着PEG分子量的增加而增强。 PAA / PEG聚合物络合物中PAA的玻璃化转变温度(Tg)转变为比PAA / PEG共混物中的PAA更低的温度。但是,随着PEG分子量的增加,它们倾向于变得更高。 PAA / PEG聚合物复合物的溶解速率比PAA / PEG共混物慢得多,并且取决于pH和PEG的分子量。 PAA / PEG聚合物复合物的粘膜粘附力比PAA / PEG共混物或市售产品Carbopol 971P NF的粘膜粘附力强。

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