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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis and characterization of the environmental-sensitive hyperbranched polymers as novel carriers for controlled drug release
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Synthesis and characterization of the environmental-sensitive hyperbranched polymers as novel carriers for controlled drug release

机译：对环境敏感的超支化聚合物的合成和表征，作为控制药物释放的新型载体

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摘要

Novel hyperbranched polymers, which contain a hydrophobic branched poly(p-(chloromethy)styrene) (PCMS) core and poly(N,N-dimethylaminoethyl methacrylate) (PDMA) shell that exhibited environmental sensitivity, have been synthesized by atom transfer radical polymerization (ATRP). At first, a hyperbranched polymer (PCMS) core is obtained via ATRP of p-(chloromethy)styrene (CMS), which may act as an "inimer"-monomer and initiator. Then the modified hyperbranched polymers having different average arm length consisting of PCMS and PDMA are synthesized by ATRP using anterior PCMS as macroinitiators. Their macromolecular structures are characterized by FTIR and H-1 NMR. Using chlorambucil as a model drug, the behaviors of the controlled drug release from the environmental-sensitive hyperbranched polymers with different average chain length of PDMA and degree of branching are studied. The data demonstrate that the rate of the drug release can be effectively controlled by pH value, and these environmental-sensitive hyperbranched polymers have the potential to be used as novel carriers in some controlled drug release systems in the future. (c) 2006 Wiley Periodicals, Inc.
机译：通过原子转移自由基聚合合成了新型超支化聚合物，该聚合物包含疏水支化的聚对（氯甲基苯乙烯）（PCMS）核和表现出环境敏感性的聚（N，N-二甲基氨基乙基甲基丙烯酸甲酯）（PDMA）壳（ ATRP）。首先，通过对-（氯甲基）苯乙烯（CMS）的ATRP获得超支化聚合物（PCMS）核，其可以充当“异构体”单体和引发剂。然后使用前PCMS作为大分子引发剂通过ATRP合成由PCMS和PDMA组成的平均臂长不同的改性超支化聚合物。它们的大分子结构通过FTIR和H-1 NMR表征。以苯丁酸氮芥为模型药物，研究了具有不同平均PDMA链长和支化度的环境敏感型超支化聚合物的受控药物释放行为。数据表明，可以通过pH值来有效控制药物的释放速率，并且这些对环境敏感的超支化聚合物有潜力在将来用于某些受控药物释放系统中作为新型载体。 （c）2006年Wiley Periodicals，Inc.

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