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首页> 外文期刊>Journal of Applied Polymer Science >Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: A novel gastro retentive drug delivery system
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Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: A novel gastro retentive drug delivery system

机译：共赋形剂对硝苯地平空心微球药物释放和漂浮性质的影响：一种新型的胃滞留药物递送系统

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摘要

A gastro retentive drug-delivery system for nifedipine was developed by incorporating the drug in cellulose acetate hollow microspheres capable of floating on the gastric and intestinal fluid. The microspheres were prepared by solvent diffusion-evaporation technique in the presence of coexcipients like polyethylene glycol, dibutyl phthalate, and poly(epsilon-caprolactone) using ethyl acetate as a dispersing solvent. Size of the microparticles depends upon the type and concentration of the excipient used. Microparticles exhibited floating properties on the simulated-gastric fluid for > 12 h. Their percentage buoyancy followed the rank order of: blank (no coexcipients) > dibutyl phthalate > polyethylene glycol > poly(epsilon-caprolactone) after 15 h of floating. Release of nifedepine was enhanced by the addition of coexcipients. The drug release followed non-Fickian transport in almost all formulations. (c) 2006 Wiley Periodicals, Inc.
机译：通过将药物掺入能够漂浮在胃和肠液中的醋酸纤维素空心微球中，开发了一种硝苯地平的胃滞留药物输送系统。在共赋形剂如聚乙二醇，邻苯二甲酸二丁酯和聚（ε-己内酯）的存在下，通过溶剂扩散-蒸发技术，使用乙酸乙酯作为分散溶剂，制备微球。微粒的大小取决于所用赋形剂的类型和浓度。微粒在模拟胃液中表现出超过12小时的漂浮特性。浮力15小时后，其浮力百分比遵循以下等级的顺序：空白（无共赋形剂）>邻苯二甲酸二丁酯>聚乙二醇>聚（ε-己内酯）。添加辅赋形剂可增强硝苯地平的释放。在几乎所有制剂中，药物的释放均遵循非费克式运输。 （c）2006年Wiley Periodicals，Inc.

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