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首页> 外文期刊>Journal of Applied Polymer Science >Stoichiometric and nonstoichiometric polyelectrolyte complex of chitosan and polyethyleneglycol-monosuccinate: Preparation and characterization
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Stoichiometric and nonstoichiometric polyelectrolyte complex of chitosan and polyethyleneglycol-monosuccinate: Preparation and characterization

机译：壳聚糖和聚乙二醇单琥珀酸酯的化学计量和非化学计量的聚电解质复合物：制备与表征

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摘要

Stoichiometric and nonstoichiometric polyelectrolyte complex (PEC) was prepared with polyethylene glycol-monosuccinate (PEGMS), and chitosan (CS). A series of PEGMS were synthesized by a 1 : 1 mol ratio between PEG and succinic anhydride. Then, the novel PEC was prepared by a various mole reaction of the above synthesized PEGMS and CS. The physicochemical properties of the synthesized PEC was characterized by using elemental analysis, FTIR, H-1, and C-13 nuclear magnetic resonance, dissolution behavior, and phase transition phenomenon. Furthermore, some properties of the PEC obtained were analyzed by UV-Visible spectrometry, wide-angle X-ray diffraction, differential scanning calorimeter, scanning electron microscope, and estimated solubility, and cell viability assay, respectively. It was found that the observed FTIR, H-1, and C-13-NMR data was in good agreement with the chemical structure of the prepared PEGMS and PEC. The dissolution behaviors of nonstoichiometric PEC were found to depend on the pH of the solution as well as on the PEGMS/CS composition. The study of MTT assay suggested that the viability of HepG2 human hepatoblastoma cell on PEC were increased significantly in accordance with mole ratio of CS. As the results, the obtained several product is a useful intermediate, which permits further chemical modification for the amino group of CS and may have potential applications in biocompatible or cosmetic systems. (c) 2007 Wiley Periodicals, Inc.
机译：用聚乙二醇单琥珀酸酯（PEGMS）和壳聚糖（CS）制备化学计量和非化学计量的聚电解质复合物（PEC）。通过PEG与琥珀酸酐之间的1：1摩尔比合成了一系列PEGMS。然后，通过上述合成的PEGMS和CS的各种摩尔反应制备新型PEC。通过元素分析，FTIR，H-1和C-13核磁共振，溶解行为和相变现象表征了合成PEC的理化性质。此外，分别通过UV-可见光谱，广角X射线衍射，差示扫描量热仪，扫描电子显微镜，估计的溶解度和细胞生存力分析来分析所获得的PEC的一些性质。发现所观察到的FTIR，H-1和C-13-NMR数据与制备的PEGMS和PEC的化学结构良好吻合。发现非化学计量的PEC的溶解行为取决于溶液的pH以及PEGMS / CS组成。 MTT法的研究表明，HepG2人肝母细胞瘤细胞在PEC上的活力随CS的摩尔比而显着增加。结果，获得的几种产物是有用的中间体，其允许对CS的氨基进行进一步的化学修饰，并且在生物相容性或化妆品体系中可能具有潜在的应用。 （c）2007年Wiley Periodicals，Inc.

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