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首页> 外文期刊>Journal of Applied Polymer Science >Photocrosslinked electrospun chitosan-based biocompatible nanofibers
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Photocrosslinked electrospun chitosan-based biocompatible nanofibers

机译：基于光交联的静电纺丝壳聚糖的生物相容性纳米纤维

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The electrospun fibers chitosan/polyvinyl alcohol (CS/PVA) were crosslinked by the incorporation of photocrosslinking agent poly(ethyleneglycol)-600-dimethacrylate (PEGDMA) and photoinitiator 2-hydroxy-1-[4-(2-hydroxyethoxy)phenyl]-2-methyl-1-propanone (HEPK) into the spinning solutions and a subsequent irradiation by UV light. The photocrosslinking process of CS-based nanofibers was studied by the Fourier transform infrared spectra, and the water resistance was investigated by scanning electron microscopy (SEM) and water swelling measurement. The results indicated that the water resistance of photocrosslinked CS-based nanofibers was improved obviously and the swelling ratio decreased with the increasing content of PEGDMA/HEPK. When the concentration of crosslinking agent was 20 wt %, the swelling ratio value decreased to half of that in none crosslinking CS/PVA nanofiber membranes, further increasing the concentration of crosslinking agent to 50 wt %, the swelling ratio value was one eighth of the none crosslinking CS/PVA nanofiber membranes. Cytotoxicity evaluation by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay indicated that the photocrosslinked CS-based fiber membranes were nontoxic to L929 cells. Results from cell culture SEM imaging showed that cells which exhibited the spindle shape could grow properly on the surface of nanofibrous structure of the CS/PVA. (C) 2008 Wiley Periodicals, Inc.
机译：通过掺入光交联剂聚（乙二醇）-600-二甲基丙烯酸酯（PEGDMA）和光引发剂2-羟基-1- [4-（2-羟基乙氧基）苯基]-使电纺纤维壳聚糖/聚乙烯醇（CS / PVA）交联。将2-甲基-1-丙酮（HEPK）放入纺丝溶液中，然后用紫外线照射。通过傅立叶变换红外光谱研究了CS基纳米纤维的光交联过程，并通过扫描电子显微镜（SEM）和水溶胀度研究了其耐水性。结果表明，随着PEGDMA / HEPK含量的增加，光交联CS基纳米纤维的耐水性明显提高，溶胀率降低。当交联剂的浓度为20 wt％时，溶胀率值降低至不交联CS / PVA纳米纤维膜的溶胀率值的一半，进一步将交联剂的浓度提高至50 wt％，溶胀率值是无交联剂的八分之一。没有交联CS / PVA纳米纤维膜。通过3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴化物测定的细胞毒性评价表明，基于光交联的CS基纤维膜对L929细胞无毒。细胞培养SEM成像结果表明，呈纺锤形的细胞可以在CS / PVA的纳米纤维结构表面上正常生长。 （C）2008 Wiley期刊公司

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