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首页> 外文期刊>Journal of Applied Polymer Science >In vitro release of salicylic acid through poly(vinyl alcohol-g-itaconic acid) membranes
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In vitro release of salicylic acid through poly(vinyl alcohol-g-itaconic acid) membranes

机译：水杨酸通过聚乙烯醇-g-衣康酸膜的体外释放

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In this study, itaconic acid (IA) was grafted on poly(vinyl alcohol) (PVA) at two different grafting percentages, 7.0% (w/w) and 14.0% (w/w), and membranes were prepared from the grafted copolymer (PVA-g-IA). Performances of PVA and PVA-g-IA membranes for the transdermal release of salicylic acid (SA) at in vitro conditions were investigated by using 2.0 mg/mL SA solutions. Effect of the pH on the release of SA was studied by keeping pH of donor and acceptor solutions in a range of (2.1-7.4). Permeation studies were also carried on at different SA concentrations. Effect of temperature on the release of SA was investigated in the temperature range of (32-39) (+/- 1)degrees C. Results showed that presence of IA decreased the release of SA from the PVA membranes and 73% SA was released at the end of 48 h at (32 +/- 1)degrees C from the IA-1 membranes. pH affected the release of SA through the grafted membranes and studies showed that release of SA was high with donor solution pH of 2.1. When the pH of donor and receiver solutions were kept at the same pH value, the overall SA% in permeate increased. Increase in concentration of SA decreased the release of SA for the studied membranes. Release of SA from PVA-g-IA membranes was temperature sensitive and increase in temperature from (32 +/- 1)degrees C to (39 +/- 1)degrees C increased the release percentage of SA by 24% (w/w). The overall activation energy for the permeation of SA through IA-I membrane was found to be 22.97 kJ/mol. (c) 2007 Wiley Periodicals, Inc.
机译：在这项研究中，衣康酸（IA）以两种不同的接枝百分比7.0％（w / w）和14.0％（w / w）接枝到聚乙烯醇（PVA）上，并从接枝共聚物制备了膜（PVA-g-IA）。通过使用2.0 mg / mL SA溶液，研究了PVA和PVA-g-IA膜在体外条件下水杨酸（SA）透皮释放的性能。通过将供体溶液和受体溶液的pH保持在（2.1-7.4）范围内，研究了pH对SA释放的影响。还以不同的SA浓度进行了渗透研究。在（32-39）（+/- 1）℃的温度范围内研究了温度对SA释放的影响。结果表明，IA的存在会降低SA从PVA膜的释放，并且73％的SA被释放在IA-1膜在（32 +/- 1）摄氏度下48小时结束时。 pH值影响通过接枝膜的SA释放，研究表明，供体溶液的pH值为2.1时SA的释放较高。当供体溶液和受体溶液的pH值保持在相同的pH值时，渗透物中的总SA％会增加。 SA浓度的增加减少了所研究膜的SA释放。 SA从PVA-g-IA膜上的释放对温度敏感，温度从（32 +/- 1）摄氏度增加到（39 +/- 1）摄氏度，SA的释放百分比提高了24％（w / w） ）。发现SA通过IA-1膜渗透的总活化能为22.97kJ / mol。 （c）2007年Wiley Periodicals，Inc.

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