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首页> 外文期刊>Journal of Applied Polymer Science >Self-Organized Nanogels from Pullulan-g-Poly(L-lactide)Synthesized by One-Pot Method: PhysicochemicalCharacterization and In Vitro Doxorubicin Release
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Self-Organized Nanogels from Pullulan-g-Poly(L-lactide)Synthesized by One-Pot Method: PhysicochemicalCharacterization and In Vitro Doxorubicin Release

机译：一锅法合成支链淀粉-g-聚（L-丙交酯）的自组织纳米凝胶：理化性质和阿霉素的体外释放

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摘要

Water-insoluble pullulan-g-poly(L-lactide)(PUPL) was successfully synthesized via a one-pot methodin the presence of triethylamine in dimethyl sulfoxide, in aneffort to design a novel anticancer agent carrier. Three sam-ples (designated as PUPL 1, 2, and 3) were obtained, whichdiffered in the moles of lactides grafted to the pullulan. Thedegrees of grafted lactide per 1 glucose unit in pullulanwere 0.68, 0.60, and 0.45 for PUPL 1, 2, and 3, respectively.These copolymers were dissolved in several organic sol-vents, including dimethyl sulfoxide, acetone, and ethanol,but were insoluble in water. The self-organized nanogelswere then prepared from the polymers via dialysis. Tostudy the organizing behavior of the polymers, their criticalassociation concentrations were measured. Their valueswere 5.0, 15.9, and 52.9 mg/L for PUPL 1, 2, and 3, respec-
机译：在三乙胺存在下于二甲基亚砜中，通过一锅法成功地合成了水不溶性支链淀粉-g-聚（L-丙交酯）（PUPL），从而设计了一种新型的抗癌剂载体。获得了三个样品（分别称为PUPL 1、2和3），它们在接枝到支链淀粉的丙交酯的摩尔数上有所不同。 PUPL 1、2和3的支链淀粉每1个葡萄糖单位的接枝丙交酯度分别为0.68、0.60和0.45。这些共聚物溶解在几种有机溶剂中，包括二甲亚砜，丙酮和乙醇，但不溶在水里。然后通过透析从聚合物制备自组织的纳米凝胶。为了研究聚合物的组织行为，测量了它们的临界缔合浓度。对于PUPL 1、2和3，其值分别为5.0、15.9和52.9 mg / L，

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