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首页> 外文期刊>Journal of Applied Polymer Science >Preparation and Characterization of Aliphatic Polyurethane and Hydroxyapatite Composite Scaffold
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Preparation and Characterization of Aliphatic Polyurethane and Hydroxyapatite Composite Scaffold

机译：脂肪族聚氨酯与羟基磷灰石复合支架的制备与表征

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摘要

Novel porous composite scaffolds for tissue engineering were prepared from aliphatic biodegradable polyurethane (PU) elastomer and hydroxyapatite (HA). It was found that the aliphatic PU was possible to load up to 50 wt % HA. The morphology and properties of the scaffolds were characterized by scanning electron microscope, X-ray diffraction, infrared absorption spectra, mechanical testing, dynamic mechanical analysis, and in vitro degradation measurement. The results indicated that the HA/PU scaffolds had an interconnected porous structure with a pore size mainly ranging from 300 to 900 lm, and 50–200 lm micropores existed on the pores’ walls. The average pore size of macropores and micropores are 510 and 100 lm, respectively. The compressive strength of the composite scaffolds showed higher enhancement with increasing HA content. In addition, the polymer matrix was completely composed of aliphatic component and exhibited progressive mass loss in vitro degradation, and the degradation rate depended on the HA content in PU matrix. The porous HA/PU composite may have a good prospect to be used as scaffold for tissue engineering.
机译：由脂肪族可生物降解的聚氨酯（PU）弹性体和羟基磷灰石（HA）制备了用于组织工程的新型多孔复合支架。发现脂族PU可以负载高达50wt％的HA。通过扫描电子显微镜，X射线衍射，红外吸收光谱，机械测试，动态力学分析和体外降解测量来表征支架的形态和性能。结果表明，HA / PU支架具有相互连接的多孔结构，孔径主要在300到900 lm之间，并且孔壁上存在50-200 lm的微孔。大孔和微孔的平均孔径分别为510和100 lm。复合支架的抗压强度随着HA含量的增加而显示出更高的增强。此外，聚合物基质完全由脂肪族成分组成，并在体外降解中表现出逐渐的质量损失，降解速率取决于PU基质中的HA含量。多孔HA / PU复合材料可能具有良好的前景，可以用作组织工程的支架。

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