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首页> 外文期刊>Journal of Applied Polymer Science >Characterization of an Anisotropic Hydrogel Tissue Substrate for Infusion Testing
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Characterization of an Anisotropic Hydrogel Tissue Substrate for Infusion Testing

机译：用于输液测试的各向异性水凝胶组织基质的表征

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摘要

Artificial tissue models that capture specific transport properties are useful for investigating physical phenomena important to drug delivery. In this study, an in vitro tissue model was developed and characterized with the goal of mimicking aligned tissue. An anisotropic porous medium was developed by the construction of a 1% agarose hydrogel implanted with different volume fractions (similar to 5, 10, and 20%) of 10-mu m-diameter glass fibers. The developed substrate was able to capture anisotropic transport after the direct infusion of a macromolecular tracer, Evans blue albumin (EBA). To further characterize the test substrate, the diffusion tensor of water was measured by diffusion tensor imaging, and the ratios of the diffusivities in the directions parallel and perpendicular to the glass fibers were 1.16, 1.20, and 1.26 for 5, 10, and 20% fiber volume fractions, respectively. The hydraulic conductivity was estimated by the measurement of pressure gradients across samples under controlled microflow conditions in the direction parallel to implanted fibers. The hydraulic conductivities at various hydrogel concentrations without fibers and in a 1% hydrogel with various fiber volume fractions were measured; for example, K-parallel to = 1.20 x 10(-12) m(4) N-1 s(-1) (where K-parallel to is the conductivity component in the direction parallel to the glass fibers) for 20% fiber volume fractions. Also, EBA distributions were fit to porous medium transport models to estimate hydraulic conductivity in the direction perpendicular to glass fibers. The estimated ratio of directional hydraulic conductivity, K-parallel to/K-perpendicular to (where K-perpendicular to is the conductivity component in the direction perpendicular to the glass fibers), ranged from approximately 3 to 5, from 6 to 10, and from 40 to 90 for 5, 10, and 20% fiber volume fractions, respectively. These agarose hydrogel models provided convenient media for quantifying infusion protocols at low flow rates.
机译：捕获特定转运特性的人工组织模型可用于研究对药物输送重要的物理现象。在这项研究中，以模仿对齐的组织为目标，开发并表征了体外组织模型。通过构造1％的琼脂糖水凝胶，开发了一种各向异性的多孔介质，其中植入了不同体积分数（类似于5、10和20％）的10微米直径玻璃纤维。直接注入大分子示踪剂埃文斯蓝白蛋白（EBA）后，已开发的底物能够捕获各向异性的转运。为了进一步表征测试基板，通过扩散张量成像测量了水的扩散张量，对于5％，10％和20％，平行和垂直于玻璃纤维的方向的扩散率分别为1.16、1.20和1.26。纤维体积分数。通过在受控的微流条件下沿平行于植入纤维的方向测量样品之间的压力梯度来估算水力传导率。测量在无纤维的各种水凝胶浓度下和在具有各种纤维体积分数的1％水凝胶中的水力传导率;例如，对于20％的纤维，K平行于= 1.20 x 10（-12）m（4）N-1 s（-1）（其中K平行于是平行于玻璃纤维方向的电导率分量）体积分数。而且，EBA分布适合于多孔介质传输模型，以估计垂直于玻璃纤维方向的水力传导率。方向性水力传导率的估计比率K平行于/ K垂直于（其中K垂直于是垂直于玻璃纤维的方向上的电导率成分）在大约3到5，从6到10的范围内，并且从40到90分别表示5％，10％和20％的纤维体积分数。这些琼脂糖水凝胶模型为定量低流速下的输注方案提供了便利的介质。

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