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首页> 外文期刊>Journal of Applied Polymer Science >The compatibility of acyclovir with polyacrylonitrile in the electrospun drug-loaded nanofibers
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The compatibility of acyclovir with polyacrylonitrile in the electrospun drug-loaded nanofibers

机译：阿昔洛韦与聚丙烯腈在电纺载药纳米纤维中的相容性

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摘要

Drug delivery systems (DDS) derived from drug-loaded fibers have attracted increasing attention inrecent years. In this study, drug-loaded nanofibers with varying drug-to-polymer ratios were prepared using electrospinning with acyclovir (ACY) as the model drug and polyacrylonitrile (PAN) as the filament-forming matrix polymer. The compatibility of ACY with PAN was investigated by FTIR, DSC, XRD, and morphological studies. The obtained results clearly demonstrated that ACY had good compatibility with PAN and was able to be evenly distributed in the polymer fiber matrix. ACY present in the drug-loaded fibers with a drug content of 10 wt % was in an amorphous state. As the ACY contents in the fibers increased up to 20 wt % drug crystals began to form and ACY separated from the fiber matrix. FTIR results illustrated that the main interactions between PAN and ACY was hydrogen bonding and data from 1H-NMR showed that ACY was able to retain its chemical integrity during the electrospinning. All the fibers with varying drug content provided sustained drug release profiles over a 12-h period. The drug-loaded fibers prepared in this study could provide new approaches for developing novel transdermal DDS or skin topical DDS.
机译：近年来，源自载有药物的纤维的药物递送系统（DDS）引起了越来越多的关注。在这项研究中，使用以阿昔洛韦（ACY）为模型药物和聚丙烯腈（PAN）作为长丝形成基质聚合物的电纺丝，制备了具有不同药物与聚合物比率的载有药物的纳米纤维。通过FTIR，DSC，XRD和形态研究研究了ACY与PAN的相容性。所得结果清楚地表明，ACY与PAN具有良好的相容性，并且能够均匀地分布在聚合物纤维基质中。存在于药物含量为10wt％的载药纤维中的ACY处于无定形状态。随着纤维中ACY含量的增加，高达20 wt％的药物晶体开始形成，ACY与纤维基质分离。 FTIR结果表明PAN与ACY之间的主要相互作用是氢键，1H-NMR数据表明ACY能够在电纺过程中保持其化学完整性。所有具有不同药物含量的纤维均在12小时内提供了持续的药物释放曲线。这项研究中制备的载药纤维可以为开发新型透皮DDS或皮肤局部DDS提供新的方法。

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