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首页> 外文期刊>Journal of Applied Polymer Science >Novel Thermo-Responsive Semi-Interpenetrating Network Microspheres of Gellan Gum-Poly(N-isopropylacrylamide) for Controlled Release of Atenolol
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Novel Thermo-Responsive Semi-Interpenetrating Network Microspheres of Gellan Gum-Poly(N-isopropylacrylamide) for Controlled Release of Atenolol

机译：吉兰糖胶（N-异丙基丙烯酰胺）的新型热响应半互穿网络微球用于阿替洛尔的控释

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摘要

Thermoresponsive microspheres of gellan gum-poly(N-isopropylacrylamide), i.e., GG-P(NIPAAm) semi-interpenetrating polymer networks (semi-IPNs) have been prepared by ionic crosslinking and used to study the controlled release (CR) of atenolol (ATL), an antihypertensive drug. Interaction of the drug with polymers was studied by Fourier transform infrared (FTIR) spectroscopy. Differential scanning calorimetry (DSC) was used to confirm the polymorphism and molecular level dispersion of ATL. Scanning electron microscopy (SEM) indicated spherical nature and smooth surfaces of the microspheres with some debris attached on their surfaces. Mean particle size measured by laser light diffraction ranged between 34 and 76 mu m. Equilibrium swelling performed at 25 degrees C and 37 degrees C in pH 7.4 phosphate buffer exhibited thermoresponsive nature of the polymers. In vitro drug release performed at 25 degrees C and 37 degrees C indicated temperature-dependency of ATL release, which was extended up to 12 h. In vitro release profiles at both the temperatures confirmed thermoresponsive nature of the polymers giving pulsatile trends. The % cumulative release data have been fitted to an empirical equation to estimate transport parameters and to understand the nature of drug release.
机译：已通过离子交联制备了吉兰糖胶-聚（N-异丙基丙烯酰胺）即GG-P（NIPAAm）半互穿聚合物网络（semi-IPNs）的热响应微球，并用于研究阿替洛尔（Atenolol）的控释（CR）（ ATL），一种抗高血压药。药物与聚合物的相互作用通过傅里叶变换红外光谱（FTIR）进行了研究。差示扫描量热法（DSC）用于确认ATL的多态性和分子水平的分散性。扫描电子显微镜（SEM）表明微球的球形性质和光滑表面，在其表面上附着有一些碎屑。通过激光衍射测量的平均粒度为34至76μm。在pH 7.4磷酸盐缓冲液中于25摄氏度和37摄氏度进行的平衡溶胀显示出聚合物的热响应性。在25摄氏度和37摄氏度下进行的体外药物释放表明ATL释放具有温度依赖性，可延长至12小时。在两个温度下的体外释放曲线证实了聚合物的热响应性，从而给出了脉动趋势。累积释放百分比数据已与经验方程式拟合，以估算转运参数并了解药物释放的性质。

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