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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis of Amphiphilic Pseudopolyamino Acid-Containing ABC-Triblock Copolymers and Micellar Characterizations
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Synthesis of Amphiphilic Pseudopolyamino Acid-Containing ABC-Triblock Copolymers and Micellar Characterizations

机译：包含两亲性伪多氨基酸的ABC-Triblock共聚物的合成和胶束表征

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摘要

This study describes the synthesis of amphiphilic ABC-triblock copolymers comprising a central pseudopoly(4-hydroxy-L-proline) segment and terminal hydrophilic poly(ethylene glycol)methyl ether as well as hydrophobic poly-(epsilon-caprolactone) blocks. Differential scanning calorimetry, H-NMR spectroscopy, and gel permeation chromatography are used to characterize the copolymers. The thermal properties (T-g and T(m)s) of the triblock copolymers depend on the composition of polymers. Larger amounts of epsilon-CL incorporated into the macromolecular backbone increased T-g and T(m)s. Fluorescence spectroscopy, transmission electron microscopy, and dynamic light scattering are utilized to investigate their micellar characteristics in the aqueous phase. Observations showed a higher critical micelle concentration with higher hydrophilic components in the copolymers. The micelle exhibited a core-shell-corona and/or vesicle shape, and the average size was less than 300 nm. Drug entrapment efficiency and drug loading of micelles depending on the composition of block polymers are also described.
机译：这项研究描述了两亲性ABC-三嵌段共聚物的合成，该共聚物包含中心假聚（4-羟基-L-脯氨酸）链段和末端亲水性聚（乙二醇）甲基醚以及疏水性聚-（ε-己内酯）嵌段。差示扫描量热法，1 H-NMR谱和凝胶渗透色谱法用于表征共聚物。三嵌段共聚物的热性质（T-g和T（m）s）取决于聚合物的组成。掺入大分子骨架的ε-CL数量增加，T-g和T（m）s增加。利用荧光光谱，透射电子显微镜和动态光散射来研究其在水相中的胶束特性。观察结果表明，共聚物中较高的临界胶束浓度和较高的亲水性组分。胶束表现出核-壳-冠状和/或囊状，平均尺寸小于300nm。还描述了取决于嵌段聚合物组成的胶束的药物截留效率和药物载量。

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