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首页> 外文期刊>Journal of Applied Polymer Science >Pectin grafted poly(N-vinylpyrrolidone): Optimization and in vitro controllable theophylline drug release
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Pectin grafted poly(N-vinylpyrrolidone): Optimization and in vitro controllable theophylline drug release

机译：果胶接枝的聚（N-乙烯基吡咯烷酮）：优化和体外可控制的茶碱药物释放

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摘要

The present article describes preparation, optimization, and characterization of pectin grafted polyvinylpyrrolidone hydrogels followed by controllable theophylline drug release. The gels were prepared in the presence of N,N′-methylenebisacrylamide (MBAA) crosslinker and ceric ammonium nitrate (CAN) initiator under N_2 atmosphere. Optimum conditions, in terms of percent of grafting (%G), were determined as follows: Pectin = 1.0 g, [NVP] = 2.81 mM, [MBAA] = 0.65 mM, [CAN] = 0.073 mM, polymerization temperature = 30°C and time = 4.0 hrs. Hydrogels were characterized by FTIR, TGA, DSC, XRD, and SEM. In vitro controllable release of theophylline model drug was studied using different N-vinylpyrrolidone monomer to MBAA crosslinker ratio (i.e., [NVP]/[MBAA] ratios) and different polymerization temperatures at two pH values, namely 5.5 and 7.4. The optimum conditions for colon-targeted vehicles that could provide the least theophylline release at pH 5.5, and the most theophylline release at pH 7.4, were as follows: [NVP]/[MBAA] = 4.33, polymerization temperature = 10°C and %G = 62.2. Such promising hydrogel characteristics may play the key role in many future drug release implementations.
机译：本文介绍了果胶接枝的聚乙烯吡咯烷酮水凝胶的制备，优化和表征，然后可控制的茶碱药物释放。在N，N'气氛下，在N，N'-亚甲基双丙烯酰胺（MBAA）交联剂和硝酸铈铵（CAN）引发剂存在下制备凝胶。以接枝百分比（％G）表示的最佳条件如下：果胶= 1.0 g，[NVP] = 2.81 mM，[MBAA] = 0.65 mM，[CAN] = 0.073 mM，聚合温度= 30° C和时间＝ 4.0小时。通过FTIR，TGA，DSC，XRD和SEM对水凝胶进行了表征。使用不同的N-乙烯基吡咯烷酮单体与MBAA交联剂比率（即[NVP] / [MBAA]比率）和在两个pH值（即5.5和7.4）下的不同聚合温度，研究了茶碱模型药物的体外可控释放。在pH 5.5时茶碱释放最少，在pH 7.4中茶碱释放最多的结肠靶向载体的最佳条件如下：[NVP] / [MBAA] = 4.33，聚合温度= 10°C和％ G = 62.2。这种有希望的水凝胶特性可能在许多未来的药物释放实施中起关键作用。

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