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首页> 外文期刊>Journal of Applied Polymer Science >Polymeric blend microspheres for controlled release of theophylline
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Polymeric blend microspheres for controlled release of theophylline

机译：聚合物共混微球可控制茶碱的释放

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摘要

Microspheres of poly(vinyl alcohol) (PVA) and hydroxyethyl cellulose (HEC) were prepared as semiinterpenetrating networks (IPNs), crosslinked with glutaraldehyde and used in controlled release of theophylline (THP), an anti-asthmatic drug. Formulations were characterized by X-ray diffraction (XRD) to understand uniform distribution of THP, Fourier transform infrared (FTIR) spectroscopy to understand chemical interactions, universal testing machine (UTM) for mechanical stability, and scanning electron microscopy (SEM) for investigating the morphology of the microspheres produced. SEM indicated smooth surfaces of the microparticles and sizes of around 10-15 lm giving high encapsulation efficiency up to 69%. Equilibrium uptake performed in double distilled water and in vitro release studies performed in 1.2 and 7.4 pH buffer media indicated the effect of extent of crosslinking and HEC content of the semi-IPN matrix on the release of THP that was extended up to 12 h. Analysis of in vitro results using empirical equation suggested a deviation from the Fickian transport. Drug diffusion was estimated from the Fick's diffusion equation for spherical geometry. Kinetics of drug release followed the Higuchi square root equation, indicating that release is diffusion-controlled.
机译：制备聚乙烯醇（PVA）和羟乙基纤维素（HEC）的微球，作为半互穿网络（IPN），与戊二醛交联，并用于茶碱（THP）（一种抗哮喘药）的控释。通过X射线衍射（XRD）来了解配方的特征，以了解THP的均匀分布，通过傅里叶变换红外（FTIR）光谱来了解化学相互作用，通过通用测试机（UTM）来评估机械稳定性，并使用扫描电子显微镜（SEM）来研究配方。产生的微球的形态。 SEM显示出微粒的光滑表面和约10-15lm的尺寸，从而提供高达69％的高封装效率。在双蒸馏水中进行的平衡吸收以及在1.2和7.4 pH缓冲液中进行的体外释放研究表明，半IPN基质的交联程度和HEC含量对THP释放的影响延长至12小时。使用经验方程对体外结果进行分析表明与菲克运移存在偏差。药物扩散是根据Fick的球形几何扩散方程估算的。药物释放的动力学遵循Higuchi平方根方程，表明释放受扩散控制。

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