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首页> 外文期刊>Journal of Applied Polymer Science >Biodegradable Polyesterurethane Networks for Controlled Release of Aspirin
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Biodegradable Polyesterurethane Networks for Controlled Release of Aspirin

机译：用于阿司匹林控制释放的可生物降解的聚氨酯网络

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摘要

In this article, poly(D,L-lactide-co-glycolide) urethane (PULG) networks were prepared from hydroxyl telechelic star-shaped oligo(D,L-lactide-co-glycolide) coupled with 1,6-diisocyanate-2,2,4-trimethylhexane and 1,6- diisocyanate-2,4,4-trimethylhexane or isophorone diisocyanate. The release of model drug aspirin (ASP) from biodegradable polyesterurethane networks was studied in phosphate buffered saline pH 7.0 at 37C. PULG networks turned from transparent to opaque after ASP loading. PULG networks with lower crosslinking density always resulted in higher drug loaded content. The results of differential scanning calorimetry and scanning electron microscope measurements demonstrated that ASP was uniformly distributed in the networks. The drug release courses of ASP from PULG networks in phosphate buffered saline pH 7.0 at 37C could be divided into three stages. Firstly, ASP release was at approximately uniform rate from PULG networks; Secondly, the release rate obviously increased due to the degradation of the PULG networks; Thirdly, the release rate decreased gradually because most of the ASP had diffused out of the PULG networks. The crosslinking density of polyesterurethane networks also affected both degradation of the polymer networks and drug release rate. The in vitro release test revealed that ASP accelerated the degradation process of PULG, which exhibited a typical erosion- controlled release mechanism.
机译：在本文中，由羟基远螯星状低聚（D，L-丙交酯-乙交酯）与1,6-二异氰酸酯-2偶联制备了聚（D，L-丙交酯-乙交酯）聚氨酯（PULG）网络。 1,2,4-三甲基己烷和1,6-二异氰酸酯-2,4,4-三甲基己烷或异佛尔酮二异氰酸酯。在37℃的磷酸盐缓冲盐水pH 7.0中研究了模型药物阿司匹林（ASP）从可生物降解的聚酯氨酯网络中的释放。加载ASP后，PULG网络从透明变为不透明。具有较低交联密度的PULG网络始终导致较高的药物负载量。差示扫描量热法和扫描电子显微镜测量的结果表明，ASP在网络中均匀分布。在37℃的磷酸盐缓冲盐水pH 7.0下，PULG网络中ASP的药物释放过程可分为三个阶段。首先，PULG网络的ASP发布速度大致相同。其次，由于PULG网络的退化，释放速率明显增加。第三，释放率逐渐下降，因为大多数ASP已从PULG网络中扩散出去。聚酯氨基甲酸酯网络的交联密度也影响聚合物网络的降解和药物释放速率。体外释放试验表明，ASP加速了PULG的降解过程，表现出典型的侵蚀控制释放机制。

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