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首页> 外文期刊>Journal of Applied Polymer Science >Carboxymethylcellulose-Chitosan-coated microneedles with modulated hydration properties
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Carboxymethylcellulose-Chitosan-coated microneedles with modulated hydration properties

机译：羧甲基纤维素-壳聚糖包衣的微针，具有调节水合作用的特性

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摘要

Microneedles containing sodium carboxymethylcellulose (CMC) formulations were fabricated to include an external chitosan (CS) layer to modulate their hydration profile, an important parameter affecting their application as intradermal delivery devices and their storage. The microfabrication process was carried out under conditions that enabled the formation of polyelectrolyte complexes between these oppositely charged macromolecules. CMC-CS microneedles were characterized by water uptake in a humid environment, contact angle measurements, dissolution in aqueous solutions, and protein-release profiles. The results demonstrate that the microneedles containing CMC-CS formulations displayed suppressed moisture sensitivity in water vapors compared to their unmodified CMC counterparts while the maintaining quick protein-release characteristics required for their uses. This approach also showed the potential for sustained protein-release applications, as the CMC-CS formulations could be combined in layers to fabricate multicompartment microneedle coatings with delayed release characteristics.
机译：含有羧甲基纤维素钠（CMC）配方的微针被制造为包括外部壳聚糖（CS）层，以调节其水合特性，这是影响其作为皮内递送装置的应用及其存储的重要参数。微加工过程是在能够在这些带相反电荷的大分子之间形成聚电解质复合物的条件下进行的。 CMC-CS微针的特征在于在潮湿环境中的水分吸收，接触角测量，在水溶液中的溶解以及蛋白质释放曲线。结果表明，与未修饰的CMC对应物相比，含CMC-CS配方的微针在水蒸气中显示出较低的水分敏感性，同时保持了其使用所需的快速蛋白质释放特性。这种方法还显示出持续释放蛋白质的潜力，因为CMC-CS制剂可以分层组合以制造具有延迟释放特性的多室微针涂层。

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