首页> 外文期刊>Journal of Applied Polymer Science >Nanoparticles prepared by blending of carboxylic acid terminated poly(ε-caprolactone) and L -phenylalanine substituted dextran
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Nanoparticles prepared by blending of carboxylic acid terminated poly(ε-caprolactone) and L -phenylalanine substituted dextran

机译:通过羧酸封端的聚(ε-己内酯)和L-苯丙氨酸取代的葡聚糖共混制备的纳米颗粒

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摘要

Preparation and characterization of nanoparticles from L-phenylalanine substituted dextrans (Dex-Phes) and carboxyl-terminated poly(ε- caprolactone) (PCL-COOH) blends in water/dimethyl sulfoxide (DMSO) (10/1, v/v) solution are reported. Dex-Phe with degree of substitution (DS) = 0.67 has good solubility in both water and DMSO, which can form the nanoparticles with PCL-COOH in water/DMSO solution. The size and size distribution of the nanoparticles were characterized by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The effect of weight ratio of PCL-COOH to Dex-Phes on particle size was investigated. A possible mechanism for the formation of nanoparticles was also proposed.
机译:在水/二甲亚砜(DMSO)(10/1,v / v)溶液中由L-苯丙氨酸取代的dextrans(Dex-Phes)和羧基端基的聚(ε-己内酯)(PCL-COOH)共混物制备和表征纳米颗粒被报道。取代度(DS)= 0.67的Dex-Phe在水和DMSO中均具有良好的溶解性,可以与PCL-COOH在水/ DMSO溶液中形成纳米颗粒。纳米颗粒的尺寸和尺寸分布通过动态光散射(DLS)和透射电子显微镜(TEM)表征。研究了PCL-COOH与Dex-Phes的重量比对粒径的影响。还提出了形成纳米颗粒的可能机理。

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