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首页> 外文期刊>Journal of Applied Polymer Science >Submicron nanoporous polyacrylamide beads with tunable size for verapamil imprinting
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Submicron nanoporous polyacrylamide beads with tunable size for verapamil imprinting

机译：亚微米级纳米多孔聚丙烯酰胺珠，具有可调节大小的维拉帕米印迹

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摘要

Submicron sized polyacrylamide particles were prepared via modified precipitation polymerization method. Experimental design based on Taguchi approach was employed to study the influence of the polymerization composition including monomer (acrylamide), crosslinker (methylenebisacrylamide), initiator (azobisisobutyronitrile), and modifier (polyvinylpyrrolidone, K-30), on the size and morphology of the particles. Varying the polymerization composition, submicron-particles with sizes ranging between 100 and 600 nm were achieved. In all the cases, polydispersity index (PDI) of the particle size was found to be almost 1 indicating uniformity of the particle size. The concentration of crosslinker was found to be the most influential parameter on the particles size and the modifier concentration as an extra tunable parameter was believed to affect the nucleation mechanism and the viscosity of the medium to help controlling the particle size. To validate the optimization, particles with a preset diameter, i.e., 500 nm, were synthesized based on the composition predicted by the mathematical correlation. The polymer with the preset particle size was also imprinted with verapamil and characterized by FTIR, DSC, SEM, physisorption, elemental analysis, swelling, and batch rebinding experiments. The verapamil imprinted polymers bearing nano-cavities exhibited high affinity with imprinting factor 2.17 towards the target molecule.
机译：通过改进的沉淀聚合方法制备了亚微米级的聚丙烯酰胺颗粒。采用基于Taguchi方法的实验设计，研究了包括单体（丙烯酰胺），交联剂（亚甲基双丙烯酰胺），引发剂（偶氮二异丁腈）和改性剂（聚乙烯吡咯烷酮，K-30）在内的聚合组成对颗粒尺寸和形态的影响。通过改变聚合组成，可以得到尺寸在100至600nm之间的亚微米颗粒。在所有情况下，发现粒度的多分散指数（PDI）几乎为1，表明粒度均匀。发现交联剂的浓度是对粒径最有影响的参数，并且认为改性剂浓度作为额外的可调节参数影响成核机理和介质的粘度以帮助控制粒径。为了验证最优化，基于数学相关性预测的组成，合成了具有预设直径即500 nm的颗粒。具有预设粒径的聚合物也被维拉帕米压印，并通过FTIR，DSC，SEM，物理吸附，元素分析，溶胀和批量重新结合实验进行了表征。带有纳米腔的维拉帕米印迹聚合物表现出对靶分子的印迹因子2.17具有高亲和力。

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