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首页> 外文期刊>Journal of Applied Polymer Science >Biological evaluation of a new organically modified ceramic-based dental restorative resin
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Biological evaluation of a new organically modified ceramic-based dental restorative resin

机译：新型有机改性陶瓷基牙齿修复树脂的生物学评估

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Material tissue interactions of a newly developed organically modified ceramic (ormocer)-based dental restorative composite based on a resin containing mixture of alkoxides of silicone and calcium with polymerizable methacrylate end groups are discussed in this study. Admira, a commercially available ormocer was used as control. A sol-gel process has been used to synthesize organically modified ceramic resins from liquid precursors, which allow one to produce inorganic-organic hybrid polymer materials, which can be functionalized to optimize their physical and chemical properties. Besides, the resulting material properties have been significantly modified by further technological processing such as photochemical curing of the materials by incorporating dimethacrylate groups as organically polymerizable units. Intracutaneous (intradermal) irritation test is found not to elicit any gross signs of tissue reaction. The results of maximization test for delayed hypersensitivity also did not show any adverse skin reaction during the induction or challenge period. Histological analysis after 1, 4, and 12 weeks of subcutaneous implantation of restorative composite resin on the dorsal surface on one side of the spinal column of Wister rats is also found not to reveal any inflammatory response after the implantation. Granuloma and material debris is found to be absent in all three periods of implantation in both test and control. No necrosis was observed around the implanted materials, which were found to be encapsulated by fibrous connective tissue consisting of predominantly fibroblasts and inflammatory cells.
机译：在这项研究中讨论了一种新开发的基于有机改性陶瓷（或增韧剂）的牙科修复复合材料的材料组织相互作用，该树脂基于含有硅酮和钙的醇盐与可聚合甲基丙烯酸酯端基的混合物的树脂。使用市售的抗癌药Admira作为对照。溶胶-凝胶工艺已用于从液体前体合成有机改性的陶瓷树脂，这使人们可以生产无机-有机杂化聚合物材料，可以对其进行功能化以优化其物理和化学性质。此外，所得的材料性能已通过进一步的技术处理得到了显着改善，例如通过引入二甲基丙烯酸酯基团作为有机可聚合单元，对材料进行光化学固化。发现皮内（皮内）刺激性试验未引起组织反应的任何明显体征。延迟超敏反应的最大化测试结果在诱导或激发期间也未显示任何不良皮肤反应。在Wister大鼠的脊柱一侧背侧皮下植入修复性复合树脂的第1、4和12周后的组织学分析也发现，植入后未发现任何炎症反应。发现在测试和对照的所有三个植入时期中都没有肉芽肿和物质碎片。在植入材料周围未观察到坏死，发现其被主要由成纤维细胞和炎性细胞组成的纤维结缔组织包裹。

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