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首页> 外文期刊>Journal of Applied Polymer Science >Preparation and evaluation of aconitine imprinted microspheres and its application to body fluid samples
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Preparation and evaluation of aconitine imprinted microspheres and its application to body fluid samples

机译：乌头碱印迹微球的制备与评价及其在体液样品中的应用

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摘要

To extract aconitine from body fluid samples, aconitine-molecularly imprinted polymer microspheres with the optimum molar ratios of template/monomer/cross-linker (1:8:40) as selective sorbents were synthesized by precipitation polymerization. Excellent retention of aconitine on the molecularly imprinted microspheres (MIMs) cartridge was achieved by optimizing the MISPE process, and the binding capacity reached 0.802mg/g, yielding an imprinting factor of 4.76. The MIMs also showed high selectivity for aconitum alkaloids, but not for other kinds of poisonous alkaloids. High recoveries (>89%) for aconitine, hypaconitine, and mesaconitine were got in spiked serum samples. The working curves show linear dependence on aconitine concentration in the range of 2.0-0.1 μg/mL, and the detection limits of aconitine, hypaconitine, and mesaconitine were 16.7, 18.3, 10.2 ng mL~(-1), respectively.
机译：为了从体液样品中提取乌头碱，乌头碱分子印迹聚合物微球具有最佳的模板/单体/交联剂摩尔比（1：8：40）作为选择性吸附剂，通过沉淀聚合法合成。通过优化MISPE工艺，乌头碱在分子印迹微球（MIMs）柱上具有出色的保留能力，结合能力达到0.802mg / g，印迹因子为4.76。 MIM对乌头生物碱也显示出高选择性，而对其他种类的有毒生物碱则没有。掺入的血清样品中乌头碱，乙酰基尼丁和甲康尼汀的回收率高（> 89％）。工作曲线显示乌头碱浓度在2.0-0.1μg/ mL范围内呈线性关系，乌头碱，hypaconitine和mesaconitine的检出限分别为16.7、18.3、10.2 ng mL〜（-1）。

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