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首页> 外文期刊>Journal of Applied Polymer Science >Fibro-porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing
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Fibro-porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing

机译：含有Biophytum敏感的提取物的纤维孔聚己内酯膜：一种预期的抗菌伤口敷料

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摘要

A fibro-porous wound dressing with antibacterial activity was fabricated from polycaprolactone (PCL) solution containing crude extract of biophytum sensitivum (BS) a potential antibacterial herbal drug. Scanning electron microscopy revealed the smooth fibrous morphology of the PCL membrane, whereas the drug-loaded PCL formed fibers with more interconnective junctions with an average fiber diameter between 1 and 3 μm. Physical characterization of the membrane revealed that it has excellent mechanical stability, water vapor transmission rate and that it promotes water uptake. The release characteristics by total immersion method in phosphate buffer and acetate buffer displayed an increase in drug release with time. Finally, the antibacterial activity of the membrane was tested against standard strains of Staphylococcus aureus and Escherichia coli. PCL membranes loaded with the drug extracts were able to inhibit the growth of bacterial strains which indicated that this fibro-porous membrane could act as a potential wound-dressing material to treat various wounds.
机译：用含有潜在潜在抗菌药草生物敏感部位（BS）的粗提取物的聚己内酯（PCL）溶液制备具有抗菌活性的纤维孔伤口敷料。扫描电子显微镜显示了PCL膜的光滑纤维形态，而载药的PCL形成了具有更多互连结的纤维，平均纤维直径在1-3μm之间。膜的物理特征表明，它具有出色的机械稳定性，水蒸气透过率，并能促进水分吸收。在磷酸盐缓冲液和乙酸盐缓冲液中通过全浸方法的释放特性显示出药物释放随时间增加。最后，测试了膜对金黄色葡萄球菌和大肠杆菌的标准菌株的抗菌活性。载有药物提取物的PCL膜能够抑制细菌菌株的生长，这表明这种纤维孔膜可以作为潜在的伤口敷料来治疗各种伤口。

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