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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis of poly[3-(methacryloylamino) propyl trimethylammonium chloride-co-methacrylic acid] copolymer hydrogels for controlled indomethacin delivery
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Synthesis of poly[3-(methacryloylamino) propyl trimethylammonium chloride-co-methacrylic acid] copolymer hydrogels for controlled indomethacin delivery

机译：用于控制消炎痛释放的聚[3-（甲基丙烯酰氨基）丙基三甲基氯化铵-甲基丙烯酸丙烯酸]共聚物水凝胶的合成

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摘要

Stimulus responsive hydrogels are being considered as one of the most exciting biomaterials of current generation. A novel hydrogel based on poly 3-[(methacryoylamino) propyl trimethylammonium chloride-co-methacrylic acid] (PMAPTACMAAc) copolymer was synthesized by free radical aqueous copolymerization. The water uptake of the hydrogels was investigated as a function of temperature and pH. The in vitro release properties of the PMAPTACMAAc hydrogels were analyzed under simulated body fluid (pH 7.4) by loading indomethacin (IND) as a model drug. The XRD study of the hydrogel revealed the amorphous nature of the copolymer and provided evidence that crystalline IND was entrapped in the hydrogel matrix. The DSC study showed the presence of single glass transition temperature in the thermogram which indicated the formation of random copolymers. The prepared hydrogels showed typical polyampholyte behavior and swelling was affected by the monomer feed ratios in the hydrogels. The morphological study on the hydrogels showed the three dimensional (3D) porous nature of the PMAPTACMAAc-5 gel with pore size ranging from 10 to 40 μm. The kinetics of the cumulative IND release shows that the gel follows a non-Fickian release mechanism. In vitro cytotoxicity of the hydrogel (PMAPTACMAAc-5 gel) on RAW 264.7 murine macrophages showed that the hydrogel was biocompatible and not toxic as the viability was maintained. The hydrogel with a 90: 10 feed ratio of MAAc and MAPTAC was better than the other developed formulations. The results suggest that the hydrogels could be employed as a sustained release formulation for targeted delivery of IND, for example to the colon.
机译：刺激响应水凝胶被认为是当前最令人兴奋的生物材料之一。通过自由基水共聚反应，合成了一种新型的基于聚3-[（甲基丙烯酰氨基）丙基三甲基氯化铵-共-甲基丙烯酸]（PMAPTACMAAc）共聚物的水凝胶。研究了水凝胶的吸水率与温度和pH的关系。通过加载吲哚美辛（IND）作为模型药物，在模拟体液（pH 7.4）下分析了PMAPTACMAAc水凝胶的体外释放特性。水凝胶的XRD研究揭示了共聚物的无定形性质，并提供了结晶IND嵌入水凝胶基质中的证据。 DSC研究表明，在热分析图中存在单个玻璃化转变温度，这表明形成了无规共聚物。制备的水凝胶显示出典型的两性电解质行为，并且溶胀受到水凝胶中单体进料比的影响。对水凝胶的形态研究表明，PMAPTACMAAc-5凝胶具有三维（3D）多孔性质，孔径范围为10至40μm。累积IND释放的动力学表明凝胶遵循非菲克式释放机理。水凝胶（PMAPTACMAAc-5凝胶）对RAW 264.7鼠巨噬细胞的体外细胞毒性表明，该水凝胶具有生物相容性，并且由于维持了生存力而没有毒性。 MAAc和MAPTAC进料比为90:10的水凝胶比其他开发的配方要好。结果表明水凝胶可用作缓释制剂，用于将IND定向递送至例如结肠。

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