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首页> 外文期刊>Journal of Applied Polymer Science >Microneedles from Fish Scale Biopolymer
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Microneedles from Fish Scale Biopolymer

机译：鱼鳞生物聚合物中的微针

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This article reports on microneedles produced from biopolymer films extracted from fish scales of tilapia (Oreochromiss sp.) using micromolding technique. Evaluation of the properties of polypeptide films prepared from the fish scales gave refractive index (1.34), protein concentration (78%), ash content (1.6%) at (22%) moisture content. The microneedles successfully inserted into artificial skin models and imaging using digital camera showed microneedles remained intact when inserted and when removed from the skin model. Microneedles also successfully inserted into porcine skin and were shown to dissolve gradually at 0 s, 60 s, 120 s, and 180 s after insertion. Microneedles containing methylene blue as model drug were also produced and successfully pierced porcine skin. 3D finite element (FEM) simulations were performed using the measured mechanical properties of the biopolymer films (Young's modulus 0.23 N/mm2 and tensile strength 1.8105 N/mm~2) to evaluate the stress distribution on various dimensions of the fish scale derived microneedles and hence, their ability to withstand force necessary to pierce the skin without fracture. Results from mechanical analysis using FEM showed that microneedles with tip radius between 10 and 100 μm could withstand up to 0.12 N of force per microneedle without fracture, which is indicated when the stress at the tip of the microneedle exceeds the ultimate stress of the material of fabrication. Using skin insertion tests and finite element simulations, this study provides evidence that microneedles fabricated from fish scale biopolymer can effectively pierce and degrade into skin and therefore are good candidate for transdermal applications.
机译：本文报道了使用微成型技术从罗非鱼鱼鳞（Oreochromiss sp。）的鱼鳞中提取的生物聚合物薄膜生产的微针。由鱼鳞制备的多肽薄膜的性能评估给出了折光指数（1.34），蛋白质浓度（78％），灰分含量（1.6％）和水分含量（22％）。将微针成功插入到人造皮肤模型中，并使用数码相机进行成像，显示当插入或从皮肤模型中取出时，微针保持完整。微针也已成功插入猪皮肤，并显示在插入后0 s，60 s，120 s和180 s逐渐溶解。还生产了含有亚甲蓝作为模型药物的微针，并成功刺穿了猪皮。使用测得的生物聚合物薄膜的机械性能（杨氏模量为0.23 N / mm2，拉伸强度为1.8105 N / mm〜2）进行3D有限元（FEM）模拟，以评估鱼鳞衍生的微针和不同尺寸的应力分布。因此，它们具有承受穿透皮肤而不会断裂所需的力的能力。使用FEM进行机械分析的结果表明，针尖半径在10到100μm之间的微针每根微针最多可承受0.12 N的力而不会断裂，这表明当微针尖处的应力超过材料的极限应力时制造。使用皮肤插入测试和有限元模拟，这项研究提供了证据，证明由鱼鳞生物聚合物制成的微针可以有效刺穿并降解成皮肤，因此是透皮应用的良好候选者。

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