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首页> 外文期刊>Journal of Applied Polymer Science >Poly(acrylic acid-co-acrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid)-Grafted Nanocellulose/Poly(vinyl alcohol) Composite for the In Vitro Gastrointestinal Release of Amoxicillin
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Poly(acrylic acid-co-acrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid)-Grafted Nanocellulose/Poly(vinyl alcohol) Composite for the In Vitro Gastrointestinal Release of Amoxicillin

机译：聚（丙烯酸-co-丙烯酰胺-co-2-丙烯酰胺基-2-甲基-1-丙磺酸）-接枝的纳米纤维素/聚乙烯醇复合材料用于阿莫西林的体外胃肠道释放

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Superabsorbent polymer composites (SAPCs) are very promising and versatile materials for biomedical applications. This study concentrates on the development of novel cellulose-based SAPC, Poly(acrylic acid-co-acrylamide-co22-acrylamido-2-methyl-1-propanesulfonic acid)-grafted nanocellulose/poly(vinyl alcohol) composite, P(AA-co-AAm-co-AMPS)-g-NC/PVA, as a potential drug delivery vehicle. Amoxicillin was selected as a model drug, which is used for the treatment of Helicobacter pylori induced peptic and duodenal ulcers. P(AA-co-AAm-co-AMPS)-g-NC/PVA was synthesized by graft copolymerization reaction, and FTIR, XRD, SEM, and DLS analyses were performed for its characterization. Equilibrium swelling studies were conducted to evaluate the stimuli-response behavior of the SAPC and found that equilibrium swelling was dependent on pH, contact time, temperature, ionic strength, concentration of crosslinker and PVA. Maximum drug encapsulation efficiency was found out by using different concentrations of amoxicillin. Drug release studies were carried out at simulated gastric and intestinal fluids and the release % was observed as maximum in intestinal fluids within 4 h. The drug release kinetics was investigated using Peppas' potential equation and follows non-Fickian mechanism at pH 7.4. Thus, the drug release experiments indicate that P(AA-co-AAm-co-AMPS)-g-NC/PVA would be a fascinating vehicle for the in vitro administration of amoxicillin into the gastrointestinal tract.
机译：高吸收性聚合物复合材料（SAPC）是非常有前途且用途广泛的生物医学材料。这项研究的重点是新型纤维素基SAPC，聚丙烯酸-共丙烯酰胺-co22-丙烯酰胺基-2-甲基-1-丙烷磺酸接枝的纳米纤维素/聚乙烯醇复合物P（AA- co-AAm-co-AMPS）-g-NC / PVA，作为潜在的药物输送工具。选择阿莫西林作为模型药物，用于治疗幽门螺杆菌引起的消化性溃疡和十二指肠溃疡。通过接枝共聚反应合成了P（AA-co-AAm-AMPS）-g-NC / PVA，并进行了FTIR，XRD，SEM和DLS分析。进行了平衡溶胀研究，以评估SAPC的刺激反应行为，发现平衡溶胀取决于pH，接触时间，温度，离子强度，交联剂浓度和PVA。通过使用不同浓度的阿莫西林发现了最大的药物包封效率。在模拟的胃液和肠液中进行了药物释放研究，观察到释放百分比在4小时内在肠液中最大。使用Peppas势方程研究了药物释放动力学，并遵循pH 7.4时的非菲克机理。因此，药物释放实验表明，P（AA-co-AAm-co-AMPS）-g-NC / PVA是将阿莫西林体外给药至胃肠道的一种引人入胜的载体。

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