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首页> 外文期刊>Journal of Applied Polymer Science >Temperature- and pH-Sensitive IPNs Grafted onto Polyurethane by Gamma Radiation for Antimicrobial Drug-Eluting Insertable Devices
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Temperature- and pH-Sensitive IPNs Grafted onto Polyurethane by Gamma Radiation for Antimicrobial Drug-Eluting Insertable Devices

机译：通过伽马辐射将温度和pH敏感的IPN嫁接到聚氨酯上，用于抗菌药物洗脱可插入设备

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摘要

Temperature- and pH-sensitive interpenetrating polymer networks (IPNs) and semi-interpenetrating polymer networks (s-IPNs) were γ-ray grafted onto polyurethane (TecoflexVR; TFX) to obtain vancomycin-eluting implantable medical devices with minimized risk of infections. N-isopropylacrylamide (NIPAAm) was grafted onto TFX catheters and films via a preirradiation oxidative method (method P) or via a direct method (method D). The PNIPAAm network facilitated acrylic acid (AAc) inclusion and subsequent polymerization/crosslinking, under specific reaction conditions. IPNs and s-IPNs systems were characterized regarding the amount of grafted polymers, surface properties (FTIR-ATR, ESEM, EDX), thermal behavior (DSC), and their temperature- and pHresponsiveness. Loading and release of vancomycin for preventing in vitro growth of Staphylococcus aureus were also evaluated. Antimicrobial activity tests and hemo- (hemolysis, protein adsorption, thrombogenicity) and cyto-compatibility (cell viability and production of cytokines and NO) assays indicated that the modification of TFX by γ-radiation may improve the performance of polyurethanes for biomedical applications.
机译：将对温度和pH敏感的互穿聚合物网络（IPN）和半互穿聚合物网络（s-IPN）进行γ射线接枝到聚氨酯（TecoflexVR; TFX）上，从而获得万古霉素洗脱的可植入医疗器械，并将感染风险降至最低。通过预辐射氧化方法（方法P）或直接方法（方法D）将N-异丙基丙烯酰胺（NIPAAm）移植到TFX导管和薄膜上。在特定的反应条件下，PNIPAAm网络促进了丙烯酸（AAc）的包容和随后的聚合/交联。 IPN和s-IPNs系统的特征在于接枝聚合物的数量，表面性质（FTIR-ATR，ESEM，EDX），热行为（DSC）及其温度和pH响应性。还评估了用于预防金黄色葡萄球菌体外生长的万古霉素的负载和释放。抗菌活性测试以及血液（溶血，蛋白质吸附，血栓形成性）和细胞相容性（细胞活力以及细胞因子和NO的产生）测定表明，通过γ射线修饰TFX可以改善聚氨酯在生物医学应用中的性能。

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