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首页> 外文期刊>Journal of Applied Polymer Science >Palm Oil-Based Organogels and Microemulsions for Delivery of Antimicrobial Drugs
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Palm Oil-Based Organogels and Microemulsions for Delivery of Antimicrobial Drugs

机译：棕榈油基有机胶和微乳剂用于抗菌药物的输送

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摘要

This study has been designed to develop palm oil (PO) based organogels using span 80/tween 80 mixture (OG) as a gelator system by fluid-filled structure mechanism. The results suggested formation of organogels, emulsions, and microemulsions as the proportions of PO, OG and water were varied. The emulsions were found to be thermodynamically unstable as compared to the organogels and the microemulsions. Accelerated thermal stability test suggested that all the microemulsions and the organogels of only eight compositions were stable. The organogels showed viscoelastic property while the microemulsions showed viscous flow behavior. Both the organogels and the microemulsions were found to be highly hemocompatible and nonirritant. The antimicrobial efficiency of the ciprofloxacin HCl-loaded formulations showed equivalent efficiency as compared to marketed formulations. The rates of drug release from the organogels were found to be relatively slower as compared to the microemulsions. The preliminary studies suggested that the developed organogel and microemulsion-based formulations may be tried for topical delivery of antimicrobials.
机译：这项研究旨在通过填充流体的结构机理，使用跨度80 /吐温80混合物（OG）作为胶凝剂系统来开发基于棕榈油（PO）的有机凝胶。结果表明，随着PO，OG和水的比例变化，会形成有机凝胶，乳液和微乳液。与有机凝胶和微乳液相比，发现乳液在热力学上是不稳定的。加速的热稳定性测试表明，只有八种组合物的所有微乳液和有机凝胶都是稳定的。有机凝胶表现出粘弹性，而微乳液表现出粘性流动行为。发现有机凝胶和微乳液都具有高度的血液相容性和无刺激性。盐酸环丙沙​​星制剂的抗菌效率与市售制剂相比具有同等效率。发现与微乳液相比，药物从有机凝胶中释放的速率相对较慢。初步研究表明，可以尝试使用已开发的有机凝胶和基于微乳剂的制剂来局部递送抗微生物剂。

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