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Recent Biomedical Advances with Polyampholyte Polymers

机译:高分子两性聚合物的最新生物医学进展

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Polyampholyte polymer systems are composed of varying mixtures of charged monomer subunits. These polymeric systems have gained increasing attention because it is possible to design the final material properties through careful selection of the charged monomer subunits and controlling the polymer architecture. Characteristics that have been manipulated include the hydration, mechanical properties, pH responsive swelling, temperature responsive swelling, resistance to nonspecific protein adsorption, and protein conjugation capability. This had led researchers to propose the use of polyampholyte polymers as biosensor platforms, fouling release membranes, drug delivery vehicles, and tissue engineering scaffolds. This review is focused on advances that have been made over the last 5 years to develop polyampholyte polymers for these biomedical applications.
机译:聚两性聚合物体系由带电单体亚基的不同混合物组成。这些聚合物体系受到越来越多的关注,因为可以通过仔细选择带电单体亚基并控制聚合物结构来设计最终的材料性能。已操纵的特征包括水合,机械性能,pH响应溶胀,温度响应溶胀,对非特异性蛋白质吸附的抵抗力和蛋白质结合能力。这促使研究人员提出使用多两性聚合物作为生物传感器平台,结垢释放膜,药物输送工具和组织工程支架。这篇综述的重点是过去5年中在开发用于这些生物医学应用的聚两性电解质聚合物方面取得的进展。

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