MS-Monitored Conjugation of Poly(ethylene glycol) Monomethacrylate to RGD Peptides

Oleg I. Bolshakov; Emmanuel O. Akala

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MS-Monitored Conjugation of Poly(ethylene glycol) Monomethacrylate to RGD Peptides

机译：质谱监测的聚乙二醇单甲基丙烯酸酯与RGD肽的偶联

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Development of biologically active polymers is an active area of research due to their applications in varied and diverse fields of biomedical research: cell adhesion, tissue proliferation, and drug delivery. Recent advances in chemical modification allow fine-tuning of the properties of biomedical polymers to improve their applications: blood circulation half-life, stimuli-responsive degradation, site-specific targeting, drug loading, etc. In this article, convergent synthesis of polymerizable macromonomers bearing a site-specific ligand (RGD peptide) using a low molecular weight MA-poly(ethylene glycols) (PEGs) is presented. The method affords macromonomers useful as the starting materials to produce biomedical polymers. We found matrix assisted laser desorption/ionization mass spectromerty convenient in monitoring the conjugation process via step-by-step following of PEG modification.

机译：由于生物活性聚合物在生物医学研究的各种领域中的应用（例如细胞粘附，组织增殖和药物递送），因此其开发是一个活跃的研究领域。化学修饰的最新进展允许微调生物医学聚合物的性能以改善其应用：血液循环半衰期，刺激性降解，位点特异性靶向，载药量等。在本文中，聚合合成可聚合的大分子单体提出了具有使用低分子量MA-聚（乙二醇）（PEG）的位点特异性配体（RGD肽）的载体。该方法提供了大分子单体，可用作生产生物医学聚合物的原料。我们发现基质辅助激光解吸/电离质谱法可方便地通过逐步进行PEG修饰来监测共轭过程。

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《Journal of Applied Polymer Science》 |2014年第14期|共6页
作者
Oleg I. Bolshakov; Emmanuel O. Akala;
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drug delivery systems; biomaterials; nanostructured polymers; molecular recognition; copolymers;

机译：药物输送系统;生物材料;纳米结构聚合物;分子识别;共聚物;

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专利

1. MS-Monitored Conjugation of Poly(ethylene glycol) Monomethacrylate to RGD Peptides [J] . Oleg I. Bolshakov, Emmanuel O. Akala Journal of Applied Polymer Science . 2014,第14期

机译：质谱监测的聚乙二醇单甲基丙烯酸酯与RGD肽的偶联
2. A biodegradable triblock copolymer poly(ethylene glycol)-b-poly(L-lactide)-b-poly(L-lysine):Synthesis,self-assembly,and RGD peptide modification [J] . Chao Deng, Xuesi Chen, Haijun Yu Polymer: The International Journal for the Science and Technology of Polymers . 2007,第26期

机译：可生物降解的三嵌段共聚物聚（乙二醇）-b-聚（L-丙交酯）-b-聚（L-赖氨酸）：合成，自组装和RGD肽修饰
3. Synthesis and Characterization of RGD Peptide Grafted Poly(ethylene glycol)-b-Poly(L-lactide)-b-Poly(L-glutamic acid) Triblock Copolymer [J] . Chao Deng, Huayu Tian, Peibiao Zhang, Biomacromolecules . 2006,第2期

机译：RGD肽接枝的聚（乙二醇）-b-聚（L-丙交酯）-b-聚（L-谷氨酸）三嵌段共聚物的合成与表征
4. RGD Peptide Modulates Osteoblast Response to Poly-L-Lysine-g-poly(ethylene glycol) Modified Surfaces [C] . S. Tosatti, Z. Schwartz, C. Campbell, Annual meeting of the Society For Biomaterials . 2003

机译：RGD肽调节成骨细胞对聚-L-赖氨酸-g-聚（乙二醇）修饰表面的响应
5. Fabrication of RGD peptide gradient poly(ethylene glycol) (PEG) hydrogel in microfluidic gradient generators to control mesenchymal stem cell behaviour. [D] . Liu, Zongbin. 2010

机译：在微流控梯度发生器中制备RGD肽梯度聚乙二醇水凝胶，以控制间充质干细胞的行为。
6. MS-Monitored Conjugation of Poly(ethylene glycol) Monomethacrylate to RGD Peptides [O] . Oleg I. Bol’shakov, Emmanuel O. Akala -1

机译：MS监测的聚乙二醇单甲基丙烯酸酯与RGD肽的偶联
7. Amino Acids and Peptides. XXX. Preparation of Arg-Gly-Asp (RGD) Hybrids with Poly(Ethylene Glycol) Analogs and Their Antimetastatic Effect. [O] . Mitsuko MAEDA, Yasuhiro IZUNO, Koichi KAWASAKI, 1997

机译：氨基酸和肽。 XXX。用聚（乙二醇）类似物及其抗体效应制备Arg-Gly-Asp（RGD）杂种。

MS-Monitored Conjugation of Poly(ethylene glycol) Monomethacrylate to RGD Peptides

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