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首页> 外文期刊>Journal of Applied Polymer Science >Bioactive Agarose Carbon-Nanotube Composites Are Capable of Manipulating Brain-Implant Interface
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Bioactive Agarose Carbon-Nanotube Composites Are Capable of Manipulating Brain-Implant Interface

机译：生物活性琼脂糖碳纳米管复合材料能够操纵脑植入界面。

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Composite electrodes made of the polysaccharide agarose and carbon nanotubes (A-CNE) have shown potential to be applied as tissue-compatible, micro-electronic devices. In this article, A-CNEs were functionalized using neuro-relevant proteins (laminin and alpha-melanocyte stimulating hormone) and implanted in brain tissue for 1 week (acute response) and 4 weeks (chronic response). Qualitative and quantitative analysis of neuronal and immunological responses revealed significant changes in immunological response to implanted materials depending on the type of biomolecule used. The potential to manipulate tissue response through the use of an anti-inflammatory protein, alpha-melanocyte stimulating hormone, was shown in the reduction of astroglia presence near the implant site during the glial scar formation. These results suggest that A-CNEs, which are soft, flexible, and easily made bioactive, have the ability to modify brain tissue response through surface modification as a function of the biomolecule used.
机译：由多糖琼脂糖和碳纳米管（A-CNE）制成的复合电极已显示出潜力，可以用作组织相容的微电子设备。在本文中，使用神经相关蛋白（层粘连蛋白和α-黑素细胞刺激激素）对A-CNE进行了功能化，并将其植入脑组织中1周（急性反应）和4周（慢性反应）。对神经元和免疫反应的定性和定量分析表明，对植入材料的免疫反应发生了显着变化，具体取决于所用生物分子的类型。通过减少神经胶质疤痕形成过程中植入部位附近的星形胶质细胞存在，可以显示出通过使用抗炎蛋白α-黑素细胞刺激激素来操纵组织反应的潜力。这些结果表明，柔软，有弹性且易于生物活性的A-CNE具有根据所用生物分子的功能通过表面修饰来修饰脑组织反应的能力。

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