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首页> 外文期刊>Journal of Applied Polymer Science >Thermally and Magnetically Dual-Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine
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Thermally and Magnetically Dual-Responsive Mesoporous Silica Nanospheres: Preparation, Characterization, and Properties for the Controlled Release of Sophoridine

机译：热和磁双响应介孔二氧化硅纳米球：制备，表征和槐定啶控释的性质。

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摘要

Novel thermally and magnetically dual-responsive mesoporous silica nanoparticles [magnetic mesoporous silica nanospheres (M-MSNs)–poly(N-isopropyl acrylamide) (PNIPAAm)] were developed with magnetic iron oxide (Fe_3O_4) nanoparticles as the core, mesoporous silica nanoparticles as the sandwiched layer, and thermally responsive polymers (PNIPAAm) as the outer shell. M-MSN–PNIPAAm was initially used to control the release of sophoridine. The characteristics of M-MSN–PNIPAAm were investigated by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetry, N_2 adsorption– desorption isotherms, and vibrating specimen magnetometry analyses. The results indicate that the Fe_3O_4 nanoparticles were incorporated into the M-MSNs, and PNIPAAm was grafted onto the surface of the M-MSNs via precipitation polymerization. The obtained M-MSN–PNIPAAm possessed superparamagnetic characteristics with a high surface area (292.44 m~2/g), large pore volume (0.246 mL/g), and large mesoporous pore size (2.18 nm). Sophoridine was used as a drug model to investigate the loading and release properties at different temperatures. The results demonstrate that the PNIPAAm layers on the surface of M-MSN–PNIPAAm effectively regulated the uptake and release of sophoridine.
机译：以磁性氧化铁（Fe_3O_4）纳米粒子为核心，以磁性多孔介孔二氧化硅纳米粒子为核心，开发了新型的热和磁双响应介孔二氧化硅纳米粒子[磁性介孔二氧化硅纳米球（M-MSNs）-聚（N-异丙基丙烯酰胺）（PNIPAAm）]夹层和热响应聚合物（PNIPAAm）作为外壳。 M-MSN–PNIPAAm最初用于控制槐定碱的释放。 M-MSN–PNIPAAm的特征通过透射电子显微镜，傅立叶变换红外光谱，X射线衍射，热重分析，N_2吸附-解吸等温线和振动样品磁力分析进行了研究。结果表明，Fe_3O_4纳米粒子被掺入M-MSNs中，并且通过沉淀聚合将PNIPAAm接枝到M-MSNs表面。所得的M-MSN-PNIPAAm具有超顺磁特性，具有高表面积（292.44 m〜2 / g），大孔体积（0.246 mL / g）和大介孔孔径（2.18 nm）。槐定碱被用作药物模型以研究在不同温度下的负载和释放特性。结果表明，M-MSN–PNIPAAm表面的PNIPAAm层有效调节了槐定碱的吸收和释放。

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