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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis and Characterization of a Drug-Delivery System Based on Melamine-Modified Poly(vinyl acetate-co-maleic anhydride) Hydrogel
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Synthesis and Characterization of a Drug-Delivery System Based on Melamine-Modified Poly(vinyl acetate-co-maleic anhydride) Hydrogel

机译：基于三聚氰胺修饰的聚醋酸乙烯酯-马来酸酐共聚物水凝胶的药物递送系统的合成与表征

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摘要

Three-dimensional polymeric networks, which quickly swell by imbibing a large amount of water or deswell in response to changes in their external environment, are called hydrogels. These types of polymeric materials are good potential candidates for drug-delivery systems. In this study, we first synthesized poly(vinyl acetate-co-maleic anhydride) by free-radical copolymerization. Then, they were modified with different molar ratios of melamine to prepare hydrogels that could be used in drug-delivery systems. The hydrogels were characterized by Fourier transform infrared spectroscopy, ~1H-NMR, differential scanning calorimetry, and scanning electron microscopy. In the second step, Ceftazidime antibiotic was loaded on selected hydrogels. The in vitro drug release was investigated and compared in three different media (HCl solution at pH=3 and buffer solutions at pH 6.1and pH 8)
机译：三维聚合网络称为水凝胶，可通过吸收大量水迅速膨胀或因其外部环境的变化而消溶，从而形成三维聚合网络。这些类型的聚合物材料是药物输送系统的良好潜在候选者。在这项研究中，我们首先通过自由基共聚合成了聚醋酸乙烯酯-顺丁烯二酸酐共聚物。然后，将它们用不同摩尔比的三聚氰胺进行改性，以制备可用于药物递送系统的水凝胶。通过傅里叶变换红外光谱，〜1H-NMR，差示扫描量热法和扫描电子显微镜对水凝胶进行表征。第二步，将头孢他啶抗生素加载到选定的水凝胶上。在三种不同的介质（pH = 3的HCl溶液和pH 6.1和pH 8的缓冲溶液）中研究并比较了体外药物释放

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