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首页> 外文期刊>Journal of Applied Polymer Science >Preparation, Characterization, and Potential Biomedical Application of Composite Sponges Based on Collagen from Silver Carp Skin
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Preparation, Characterization, and Potential Biomedical Application of Composite Sponges Based on Collagen from Silver Carp Skin

机译：银鲤皮胶原蛋白复合海绵的制备，表征及生物医学应用前景

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摘要

To reuse fish processing waste for biomedical materials, collagen (Col) was extracted from silver carp skin, and Col-chitosan (Ch) composite sponges were prepared by a freeze-drying method. The atomic force microscopy and electrophoresis results suggest the Col might have been type I. To obtain the optimum conditions for the manufacture of the Col-Ch sponges, the characteristics of sponges composed of different ratios of Col to Ch with different crosslinkers were evaluated. Scanning electron microscopy showed that the sponges had an interconnected network structure with porosity. Infrared spectroscopy demonstrated that intermolecular crosslinkages between Col and Ch occurred. The swelling measurements implied that all of the sponges could bind an 18- to 36-fold amount of distilled water and still maintain their form and stability. When the ratio of Col to Ch was higher than 1:0.25, the swelling and degradation rate decreased with increasing Ch. Cell proliferation, hemolysis, and hemostasis assay indicated that the sponges exhibited noncytotoxicity, biocompatibility, nonhemolysis, and hemostatic efficacy. Overall, we concluded that the optimal ratio of Col and Ch for the sponges was 1:0.25, and glutaraldehyde crosslinking was more suitable than 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride. These results demonstrate the potential application of silver carp skin Col-Ch sponges for tissue engineering and wound dressing in non-weight-bearing tissue. VC 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40998.
机译：为了将鱼类加工废料再用于生物医学材料，从silver鱼皮中提取了胶原蛋白（Col），并通过冷冻干燥方法制备了Col-壳聚糖（Ch）复合海绵。原子力显微镜和电泳结果表明，该Col可能是I型。为了获得制造Col-Ch海绵的最佳条件，评估了由不同的Col / Ch比例和不同的交联剂组成的海绵的特性。扫描电子显微镜显示，海绵具有相互连接的网状结构且具有孔隙。红外光谱表明Col和Ch之间发生了分子间的交联。溶胀度测量结果表明，所有海绵都可以结合18至36倍量的蒸馏水，并且仍然保持其形状和稳定性。当Col与Ch的比例高于1：0.25时，溶胀和降解速率随Ch的增加而降低。细胞增殖，溶血和止血分析表明，海绵具有非细胞毒性，生物相容性，非溶血性和止血功效。总的来说，我们得出结论：海绵的Col和Ch最佳比例为1：0.25，戊二醛交联比1-乙基-3-（3-二甲基氨基丙基）碳二亚胺盐酸盐更合适。这些结果证明silver鱼皮Col-Ch海绵在非承重组织中用于组织工程和伤口敷料的潜在应用。 VC 2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2014，131，40998。

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