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首页> 外文期刊>Journal of Applied Polymer Science >Designing and Preparing of Quercetin Surface-Imprinted Material and Its Molecular Recognition Characteristics
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Designing and Preparing of Quercetin Surface-Imprinted Material and Its Molecular Recognition Characteristics

机译：槲皮素表面印迹材料的设计，制备及其分子识别特性

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摘要

Quercetin is an important compound of flavonoids. In this work, quercetin molecule surface-imprinted material with high performance was prepared using a novel surface-imprinting technique of “synchronously graft-polymerizing and imprinting.” The modified micron-sized silica gel particles containing amino groups were used as matrix, methacrylic acid (MAA) was used as functional monomer, and N,N′-Methylenebisacrylamide (MBA) was used as crosslinker. In dimethyl formamide solution of quercetin, MAA molecules arranged automatically around the template quercetin molecule by right of hydrogen bonding interactions of two type, ordinary hydrogen bond and π-type hydrogen bond. By initiating the surface-initiating system of –NH_2/S_2O_8~(2-), the graft/crosslinking polymerization of MAA on SiO_2 particles and the quercetin molecule surface-imprinting were simultaneously carried out, forming quercetin molecule surface-imprinted material MIP-PMAA/SiO_2. With another two flavonoids, rutin and genistein, as contrasting substances, the molecule recognition character of the quercetin molecule surface-imprinted material MIP-PMAA/SiO_2 was investigated with batch and column methods. The experimental results show that the imprinted material MIP-PMAA/SiO_2 possesses special recognition selectivity and excellent binding affinity for quercetin molecule. The binding capacity of MIP-PMAA/SiO_2 for quercetin is 0.325 mmol/g, and its selectivity coefficients for quercetin relative to rutin and genistein are 7.69 and 4.40, respectively. The main conditions of imprinting process affect the property of MIP-PMAA/SiO_2 greatly, and the optimal molar ratio of monomer MAA to crosslinker MBA is 7 : 1 and appropriate molar ratio of monomer MAA to template quercetin is equal to 6 : 1.
机译：槲皮素是一种重要的类黄酮化合物。在这项工作中，使用“同步接枝聚合和压印”的新型表面压印技术制备了高性能的槲皮素分子表面压印材料。包含氨基的改性微米级硅胶颗粒用作基质，甲基丙烯酸（MAA）用作功能单体，N，N'-亚甲基双丙烯酰胺（MBA）用作交联剂。在槲皮素的二甲基甲酰胺溶液中，MAA分子通过普通氢键和π型氢键这两种类型的氢键相互作用而自动排列在模板槲皮素分子周围。通过引发–NH_2 / S_2O_8〜（2-）的表面引发体系，同时进行MAA在SiO_2颗粒上的接枝/交联聚合和槲皮素分子的表面压印，形成了槲皮素分子的表面压印材料MIP-PMAA / SiO_2。以另外两种类黄酮，芦丁和染料木黄酮为对比物质，采用分批法和柱法研究了槲皮素分子表面印迹材料MIP-PMAA / SiO_2的分子识别特性。实验结果表明，印迹材料MIP-PMAA / SiO_2具有特殊的识别选择性和对槲皮素分子的优良结合亲和力。 MIP-PMAA / SiO_2与槲皮素的结合能力为0.325 mmol / g，相对于芦丁和染料木黄酮，槲皮素的选择性系数分别为7.69和4.40。压印工艺的主要条件极大地影响了MIP-PMAA / SiO_2的性能，单体MAA与交联剂MBA的最佳摩尔比为7：1，单体MAA与模板槲皮素的适当摩尔比为6：1。

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