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首页> 外文期刊>Journal of Applied Polymer Science >Biocompatible and Biodegradable Alginate/Poly(N-isopropylacrylamide) Hydrogels for Sustained Theophylline Release
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Biocompatible and Biodegradable Alginate/Poly(N-isopropylacrylamide) Hydrogels for Sustained Theophylline Release

机译：生物相容性和可生物降解的藻酸盐/聚（N-异丙基丙烯酰胺）水凝胶，用于持续释放茶碱

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摘要

Mixed-interpenetrated polymeric networks based on sodium alginate (ALG) and poly(N-isopropylacryl amide) (PNIPAAm) covalently cross-linked with N,N'-methylenebisacrylamide are studied for their biocompatibility, nontoxicity, and biodegradability aiming their application in drug delivery. The presence of drug-polymeric matrix interactions and the distribution of the drug in the polymeric network for theophylline-loaded ALG/PNIPAAm hydrogels are also investigated by spectroscopic and microscopic methods. The quantitative evaluation of theophylline loaded hydrogels performed by NIR-CI technique shows a better drug entrapment and a higher homogeneity of the samples with increased alginate content. The thermal behavior of the hydrogels is significantly modified by theophylline presence. The application of the ALG/PNIPAAm hydrogels as carriers for sustained drug release formulations was assessed by the theophylline release tests performed both by in vitro and in vivo studies.
机译：研究了基于藻酸钠（ALG）和与N，N'-亚甲基双丙烯酰胺共价交联的聚（N-异丙基丙烯酰胺）（PNIPAAm）的混合互穿聚合物网络的生物相容性，无毒性和生物降解性，旨在将其应用于药物递送中。还通过光谱和显微镜方法研究了负载茶碱的ALG / PNIPAAm水凝胶的药物-聚合物基质相互作用的存在以及聚合物在聚合物网络中的分布。通过NIR-CI技术对负载茶碱的水凝胶进行定量评估表明，随着藻酸盐含量的增加，药物的截留效果更好，样品的均质性更高。茶碱的存在大大改变了水凝胶的热行为。 ALG / PNIPAAm水凝胶作为缓释制剂载体的应用通过体外和体内研究进行的茶碱释放测试进行了评估。

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