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首页> 外文期刊>Journal of Applied Polymer Science >Drug-Loaded Polyurethane/Clay Nanocomposite Nanofibers for Topical Drug-Delivery Application
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Drug-Loaded Polyurethane/Clay Nanocomposite Nanofibers for Topical Drug-Delivery Application

机译：用于局部药物递送应用的载药聚氨酯/粘土纳米复合纳米纤维

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摘要

In this study, polyurethaneanoclay nanocomposite nanofibrous webs were prepared by electrospinning. An antiseptic drug, chlorhexidine acetate (CA), was loaded onto montmorillonite clay and was then incorporated into polyurethane nanofibers. For comparison, the CA drug was loaded directly into the polyurethane solution dope used to electrospin the nanofibers. The emphasis was on investigating the effect of the drug loading into the nanoclay vis-à-vis direct drug loading on the drug-release behavior of nanofibrous webs. The nanofibrous webs were also evaluated for other properties, such as moisture vapor transmission, porosity determination, contact angle measurement, and antibacterial activity, which are important for topical drug-delivery application.
机译：在这项研究中，聚氨酯/纳米粘土纳米复合纳米纤维网是通过静电纺丝制备的。将一种抗菌药物醋酸洗必太（CA）加载到蒙脱土上，然后掺入聚氨酯纳米纤维中。为了进行比较，将CA药物直接装入用于静电纺丝纳米纤维的聚氨酯溶液涂料中。重点是研究相对于直接药物加载而言，纳米粘土中药物加载对纳米纤维网药物释放行为的影响。还评估了纳米纤维网的其他性能，例如湿气透过率，孔隙率确定，接触角测量和抗菌活性，这些对于局部药物递送应用很重要。

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