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首页> 外文期刊>Journal of Applied Polymer Science >Comparison of the Antibacterial Activity of Modified-Cotton with Magainin I and LL-37 with Potential as Wound-Dressings
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Comparison of the Antibacterial Activity of Modified-Cotton with Magainin I and LL-37 with Potential as Wound-Dressings

机译：Magainin I和LL-37潜在作为伤口敷料的改性棉的抗菌活性比较

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摘要

Wounds are the ideal setting for the development of micro-organisms, so it is often necessary to apply a dressing to control bacterial colonization. Cotton is commonly used in dressings, as it exhibits important hydrophilic characteristics such as high moisture and fluid retention properties, but it may provide a sustainable media for the development of micro-organisms. In this way, the development of new strategies to provide cotton materials with lasting and effective antimicrobial properties is of the utmost importance. Consequently, here we described two processes to develop cotton-dressings functionalized with antimicrobial peptides (AMPs) magainin I (MagI) and LL-37, in order to give cotton-dressings an antibacterial effect. The AMPs showed no cytotoxic effect against human fibroblasts so they are safe to contact with skin. In addition, the functionalized materials with either LL-37 or MagI present an antimicrobial effect exhibiting inhibition ratios of 89% against Klebsiella pneumoniae and 58% against Staphylococcus aureus, respectively. VC 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40997.
机译：伤口是微生物生长的理想环境，因此通常有必要使用敷料来控制细菌定植。棉花通常用于敷料中，因为它具有重要的亲水特性，例如高水分和保水性，但它可以为微生物的发展提供可持续的培养基。以这种方式，为棉材料提供持久和有效的抗菌性能的新策略的发展至关重要。因此，在此我们描述了开发用抗微生物肽（AMPs）麦角菌素I（MagI）和LL-37功能化的棉制衣料的两种方法，以使棉制衣料具有抗菌作用。 AMP对人成纤维细胞没有细胞毒性作用，因此可以安全地与皮肤接触。此外，具有LL-37或MagI的功能化材料具有抗微生物作用，分别对肺炎克雷伯菌和金黄色葡萄球菌的抑制率分别为89％和58％。 VC 2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2014，131，40997。

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