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首页> 外文期刊>Journal of Applied Polymer Science >Vitamin E Acetate Addition to Poly(D,L)Lactic Acid Modifies Its Mechanical Behavior Without Affecting Biocompatibility
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Vitamin E Acetate Addition to Poly(D,L)Lactic Acid Modifies Its Mechanical Behavior Without Affecting Biocompatibility

机译：聚（D，L）乳酸中添加维生素E乙酸酯可改变其机械行为，而不会影响生物相容性

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摘要

Mechanical properties of poly(D,L)lactic acid films enriched with Vitamin E and Vitamin E Acetate (5-40% w/w) were investigated. The addition of both formulations resulted in increased polymer Young's modulus and tensile strength. Human foreskin fibroblasts and murine pre-osteoblasts were used to assess the biocompatibility of polymers. Pre-osteoblasts adhesion and proliferation were strongly decreased by Vitamin E, whereas Vitamin E Acetate did not alter cell proliferation. Collagen deposition was lower onto Vitamin E blended polymers than onto native and Vitamin E Acetate blended ones. Fibroblasts adhesion and proliferation were increased by both Vitamin E and Vitamin E Acetate addition.
机译：研究了富含维生素E和乙酸维生素E（5-40％w / w）的聚（D，L）乳酸膜的机械性能。两种配方的添加均导致聚合物的杨氏模量和拉伸强度提高。人类包皮成纤维细胞和鼠成骨细胞被用来评估聚合物的生物相容性。维生素E大大降低了成骨前细胞的粘附和增殖，而乙酸维生素E并没有改变细胞增殖。维生素E混合聚合物上的胶原蛋白沉积要比天然和醋酸E乙酸酯混合聚合物上的胶原蛋白沉积低。维生素E和维生素E醋酸盐的添加均可增加成纤维细胞的粘附和增殖。

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