• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Applied Polymer Science >Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers: Preparation, characterization, and anti-adhesion activity
【24h】

Flurbiprofen axetil loaded coaxial electrospun poly(vinyl pyrrolidone)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers: Preparation, characterization, and anti-adhesion activity

机译：氟比洛芬酯载同轴电纺丝聚乙烯吡咯烷酮-纳米聚乳酸-乙醇酸核壳复合纳米纤维的制备，表征和抗粘着活性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Flurbiprofen axetil (FA)-loaded coaxial electrospun poly(vinyl pyrrolidone) (PVP)-nanopoly(lactic-co-glycolic acid) core-shell composite nanofibers were successfully fabricated by a facile coaxial electrospinning, and an electrospun drug-loaded system was formed for anti-adhesion applications. The FA, which is a kind of lipid microsphere nonsteroidal anti-inflammatory drug, was shown to be successfully adsorbed in the PVP, and the formed poly(lactic-co-glycolic acid) (PLGA)/PVP/FA composite nanofibers exhibited a uniform and smooth morphology. The cell viability assay and cell morphology observation revealed that the formed PLGA/PVP/FA composite nanofibers were cytocompatible. Importantly, the loaded FA within the PLGA/PVP coaxial nanofibers showed a sustained-release profile and anti-adhesion activity to inhibit the growth of the IEC-6 and NIH3T3 model cells. With the significantly reduced burst-release profile, good cytocompatibility, and anti-adhesion activity, the developed PLGA/PVP/FA composite nanofibers were proposed to be a promising material in the fields of tissue engineering and pharmaceutical science. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41982.
机译：简便的同轴电纺技术成功制备了氟比洛芬酯（FA）负载的同轴电纺丝聚乙烯吡咯烷酮（PVP）-纳米聚（乳酸-乙醇酸）核壳复合纳米纤维，并形成了电纺丝负载药物体系用于防粘应用。 FA是一种脂质微球非甾体类抗炎药，已成功吸附在PVP中，形成的聚乳酸-乙醇酸（PLGA）/ PVP / FA复合纳米纤维表现出均一性和平滑的形态。细胞活力测定和细胞形态观察表明，所形成的PLGA / PVP / FA复合纳米纤维具有细胞相容性。重要的是，PLGA / PVP同轴纳米纤维中负载的FA显示出缓释曲线和抗粘附活性，从而抑制了IEC-6和NIH3T3模型细胞的生长。具有显着降低的爆发释放特性，良好的细胞相容性和抗粘附活性，开发的PLGA / PVP / FA复合纳米纤维被认为是组织工程和药学领域的有前途的材料。 （c）2015 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，41982。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号