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首页> 外文期刊>Journal of Applied Polymer Science >Development and Characterization of Gelatin-Based Hydrogels, Emulsion Hydrogels, and Bigels: A Comparative Study
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Development and Characterization of Gelatin-Based Hydrogels, Emulsion Hydrogels, and Bigels: A Comparative Study

机译：明胶基水凝胶，乳液水凝胶和Bigels的开发和表征：对比研究

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This study was designed to examine the physicochemical and electrical properties of gelatin-based hydrogels, emulgels, and bigels. The chemical studies suggested an increase in hydrogen bonding in the emulgel and bigel when sesame oil (SO; representative vegetable oil) and SO organogel (OG; representative OG) were incorporated within the gelatin matrix. The emulgel and bigel showed better mechanical properties and higher electrical impedances compared to the hydrogel. The hydrogel showed similar swelling at pH 1.2 and 7.2. The swelling of the emulgel and bigel was higher at pH 7.2. The formulations were found to be highly hemocompatible; this indicated their biocompatible nature. Ciprofloxacin, a model antimicrobial drug, was incorporated within the formulations. The release of the drug was found to be diffusion-mediated. The antimicrobial efficiency of all of the drug-loaded formulations was found to be equivalent. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41502.
机译：这项研究旨在检查基于明胶的水凝胶，乳胶和比格尔斯的理化性质和电性质。化学研究表明，当在明胶基质中掺入芝麻油（SO;代表性植物油）和SO有机凝胶（OG;代表性OG）时，乳胶和比格尔胶中的氢键增加。与水凝胶相比，Emulgel和Bigel具有更好的机械性能和更高的电阻抗。水凝胶在pH 1.2和7.2下显示出类似的溶胀。在pH 7.2时，Egelgel和Bigel的溶胀度更高。发现该制剂具有高度的血液相容性。这表明它们具有生物相容性。环丙沙星是一种典型的抗菌药物，已掺入制剂中。发现药物的释放是扩散介导的。发现所有载药制剂的抗微生物效力是等效的。 （c）2014 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，41502。

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