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首页> 外文期刊>Journal of Applied Polymer Science >Arrays of Polyacrylamide Hydrogels Using a Carbodiimide-Mediated Crosslinking Reaction
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Arrays of Polyacrylamide Hydrogels Using a Carbodiimide-Mediated Crosslinking Reaction

机译：使用碳二亚胺介导的交联反应的聚丙烯酰胺水凝胶阵列

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摘要

This study introduces a radical-free approach for generating polyacrylamide (PAM) hydrogels with no toxic residues remaining in the networks. Acrylamide and bisacrylamide, which are neurotoxins, are not used during the hydrogel synthesis and only nontoxic side products are generated. This is achieved using a gentle carbodiimide-mediated crosslinking (CMCL) reaction that does not require complex initiation systems and is effective in the presence of oxygen. This overcomes some of the key limitations related to PAM hydrogel synthesis using free-radical routes and maintains the advantages of synthetic hydrogels over biopolymers. In addition, the CMCL reaction allows for accurate placement of functional groups, which controls hydrogel structure and performance including mechanical strength, swelling capacity, and hydrophobic balance. This flexibility is demonstrated through the synthesis and rheological characterization of a library of structurally diverse hydrogels as well as spherical hydrogels. PAM-based hydrogels are used extensively in a broad number of applications, and this study demonstrates the applicability of this method as a nontoxic and radicalfree complementary alternative route that can generate structures analogous to those prepared using free-radical routes.
机译：这项研究引入了一种无自由基的方法来生成聚丙烯酰胺（PAM）水凝胶，而在网络中没有残留的毒性残留物。神经毒素丙烯酰胺和双丙烯酰胺在水凝胶合成过程中不使用，仅产生无毒的副产物。这是使用温和的碳二亚胺介导的交联（CMCL）反应实现的，该反应不需要复杂的引发系统，并且在有氧条件下有效。这克服了与使用自由基途径合成PAM水凝胶有关的一些关键限制，并保持了合成水凝胶优于生物聚合物的优势。此外，CMCL反应可精确放置官能团，从而控制水凝胶的结构和性能，包括机械强度，溶胀能力和疏水平衡。这种灵活性通过结构多样的水凝胶和球形水凝胶库的合成和流变学表征得到证明。基于PAM的水凝胶在许多应用中得到了广泛使用，并且这项研究证明了该方法作为无毒且无自由基互补的替代途径的适用性，该替代途径可以产生类似于使用自由基途径制备的结构。

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