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首页> 外文期刊>Journal of Applied Polymer Science >Dual drug release from CO2-infused nanofibers via hydrophobic and hydrophilic interactions
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Dual drug release from CO2-infused nanofibers via hydrophobic and hydrophilic interactions

机译：通过疏水和亲水相互作用从注入二氧化碳的纳米纤维中释放双重药物

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This study investigated the effects of hydrophobic-hydrophilic interactions on dual drug release from CO2-infused nanofibers scaffolds (PCL, PCL-gelatin, and PCL core PCL-gelatin shell) using BODIPY 493/503 and Rhodamine B fluorescent dyes as drug models. Favorable dye-scaffold interactions increased total dye loading and promoted steady, more linear release. Unfavorable dye-scaffold interactions reduced overall loading and led to a greater burst release of dye. However, when CO2 was used to infuse dye into an unfavorable scaffold, the changes in loading and release were less pronounced. When two dyes were infused, these behaviors were accentuated due to interactions between the dissolved forms of the dyes. Core-shell composite nanofibers displayed radically different release properties versus pure PCL-gelatin fibers when treated with dyes via CO2 infusion. Dye release from core-shell scaffolds was highly sensitive to both interactions with scaffolds and the phase of CO2 used to infuse the compounds of interest. By using different phases of CO2 to partition dyes into hydrophobic and hydrophilic sections of core-shell nanofibers, such interactions can be manipulated to develop a bimodal drug release system with potential application in drug delivery or tissue engineering. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42571.
机译：这项研究使用BODIPY 493/503和罗丹明B荧光染料作为药物模型，研究了疏水-亲水相互作用对注入CO2的纳米纤维支架（PCL，PCL-明胶和PCL核心PCL-明胶壳）中双重药物释放的影响。有利的染料-支架相互作用增加了染料的总负载量，并促进了稳定的线性释放。不利的染料-支架相互作用降低了总负载并导致更大的染料猝发释放。然而，当使用CO 2将染料注入不利的支架中时，负载和释放的变化不太明显。当注入两种染料时，由于染料的溶解形式之间的相互作用，这些行为更加突出。与纯PCL-明胶纤维相比，核-壳复合纳米纤维在通过CO2注入进行染料处理后显示出与纯PCL-明胶纤维完全不同的释放性能。从核-壳支架中释放的染料对与支架的相互作用以及用于注入目标化合物的二氧化碳相都非常敏感。通过使用不同阶段的CO2将染料分配到核-壳纳米纤维的疏水和亲水部分，可以操纵这种相互作用来开发一种双峰药物释放系统，在药物输送或组织工程中具有潜在的应用前景。 （c）2015 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，42571。

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